Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 12,500 | |||
5 mg | 在庫あり | ¥ 29,500 | |||
10 mg | 在庫あり | ¥ 43,500 | |||
25 mg | 在庫あり | ¥ 91,500 | |||
50 mg | 在庫あり | ¥ 136,000 | |||
100 mg | 在庫あり | ¥ 194,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 33,000 |
説明 | Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo. |
ターゲット&IC50 | Kv7.1:3.7 μM(Ki), Kv7.4:230 μM(Ki), Kv7.5:605 μM(Ki) |
In vitro | Flindokalner inhibits cardiac L-type Ca2+ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes. Flindokalner (10 μM) inhibits Kv7.4and Kv7.5 (Kis: 230 and 605 μM, respectively)[1]. Flindokalner (1-10 μM) causes inhibition of the Ca2+ current in a dose-dependent manner (Kd: 6 μM and a Hill coefficient: 1.33) [2]. |
In vivo | Flindokalner (3-60 mg/kg; i.p.) engenders an anxiolytic profile, in a shock-based conditioned model of anxiety in male Wistar rats. Flindokalner (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect [1]. |
別名 | BMS-204352 |
分子量 | 359.7 |
分子式 | C16H10ClF4NO2 |
CAS No. | 187523-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (278.01 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Flindokalner 187523-35-9 Membrane transporter/Ion channel Potassium Channel inhibit KcsA neuronal ventricular effects anxiolytic BMS204352 BMS-204352 subtype Inhibitor myocytes BMS 204352 current inhibitor