Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 53,500 | |||
50 mg | 在庫あり | ¥ 88,000 | |||
100 mg | 在庫あり | ¥ 128,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 18,500 |
説明 | ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. |
ターゲット&IC50 | KCNQ2/Q3 K+ channel:0.38 μM (EC50) |
In vitro | ICA-27243 increases both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM). ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine, in SH-SY5Y human neuroblastoma cells [1]. |
In vivo | In the mouse maximal electroshock epilepsy model, ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50: 8.4 mg/kg)[1]. |
分子量 | 268.65 |
分子式 | C12H7ClF2N2O |
CAS No. | 325457-89-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 247 mg/mL (919.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ICA-27243 325457-89-4 Membrane transporter/Ion channel Potassium Channel antiepileptic hyperpolarization opener ICA 27243 Inhibitor KcsA ICA27243 inhibit KCNQ3 KCNQ2 anticonvulsant inhibitor