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T15545 |
ICA-27243
|
|
Potassium Channel
|
|
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. |
|
T3563 |
Lvguidingan
|
|
Others
|
|
Lvguidingan is an Anticonvulsant agent. |
|
T1052 |
Proglumide
|
|
cholecystokinin
|
|
Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is... |
|
T0939 |
Phenytoin
|
Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease
,
Sodium Channel
|
|
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor... |
|
T8937 |
Soticlestat
|
TAK-935,OV935 |
P450
|
|
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. |
|
T0192 |
Levetiracetam
|
UCB L059,SIB-S1 |
DNA Methyltransferase
,
Others
,
Calcium Channel
|
|
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... |
|
T0008 |
Phenytoin sodium
|
5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium |
Virus Protease
,
Sodium Channel
|
|
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel . |
|
T0128L |
Vigabatrin Hydrochloride
|
γ-Vinyl-GABA hydrochloride |
GABA Receptor
|
|
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly inhibits the catabolism of GABA by GABA transaminase. |
|
T16427 |
Padsevonil
|
UCB-0942 |
Others
|
|
Padsevonil is an effective antiepileptic compound. |
|
T0628 |
Iminodibenzyl
|
|
Others
|
|
Iminodibenzyl is used for the intermediates of antiepileptic drug carbamazepine. |
|
T14863 |
Carabersat
|
SB 204269 |
Others
|
|
Carabersat（SB 204269） is a novel and effective anticonvulsant and antiepileptic agent. |
|
T31354 |
Decimemide
|
V 285,V-285,V285 |
Others
|
|
Decimemide (V-285) is an alkoxybenzoic acid derivative with antiepileptic activity and potential anticonvulsant activity that can be used to study neurological disorders. |
|
T73586 |
Anticonvulsant agent 2
|
|
Others
|
|
Anticonvulsant agent 2 is a potent orally active anticonvulsant that has shown antiepileptic activity in a model of drug-resistant epilepsy. |
|
T11278 |
FG8119
|
NNC13-8119 |
Others
|
|
FG8119 is a novel benzodiazepine agonist with potential anticonvulsant and antiepileptic activity for the study of neurological disorders. |
|
T0028 |
Gamibetal
|
3-Hydroxy-GABA,4-Amino-3-hydroxybutyric Acid |
HIV Protease
|
|
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Ac... |
|
T16960 |
Sultiame
|
|
Others
,
Carbonic Anhydrase
|
|
Sultiame is an inhibitor of carbonic anhydrase. |
|
T3562 |
Valrocemide
|
TV1901,N-Valproylglycinamide |
Others
|
|
Valrocemide (TV1901), also known as TV-1901, is an antiepileptic drug (AED). Valrocemide has a broad spectrum of anticonvulsant activity and promising potential as a new AED. Valrocemide is an anticonvulsant agent under ... |
|
T0283 |
Trimethadione
|
3,5,5,-Trimethyloxazolidine-2,4-dione |
Calcium Channel
|
|
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity. |
|
T28655 |
Sabeluzole
|
R 58735,R58735,R-58735 |
Microtubule Associated
|
|
Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.Sabeluzole is protective against chlordiazepoxide-induced habituation disorders and may be... |
|
TNU0187 |
2',5-Difluoro-2'-deoxy-1-arabinosyluracil
|
2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine |
Nucleoside Antimetabolite/Analog
|
|
2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic and antihypertensive activity, which can be used to study an... |
|
T22171 |
WWL123
|
|
MAGL
|
|
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole... |
|
T13112 |
Tat-NR2B9c
|
Tat-NR2Bct,NA-1 |
NO Synthase
,
iGluR
|
|
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi... |
|
T6474 |
Divalproex Sodium
|
Valproate semisodium,Epival |
HDAC
|
|
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... |
|
T26017 |
R 57720
|
R57720,R-57720 |
|
|
R 57720 is an antiepileptic agent. |
|
T30848 |
CGP-47292
|
CGP 47,292,UNII-266244C47B,CGP 47292 |
|
|
CGP-47292 is a metabolite of the novel antiepileptic compound CGP 33,101. |
|
T23651 |
AF-CX 921XX
|
AF-CX 921,AF-CX-921-XX |
|
|
AF-CX 921XX is an antiepileptic agent. |
|
T23986 |
Dezinamide
|
ADD94057,ADD-94057,ADD 94057 |
|
|
Dezinamide is a potential antiepileptic drug. It shows preliminary evidence of efficacy and safety in an open-label study. |
|
T14281 |
Becampanel
|
AMP 397 |
Others
|
|
|
|
T23567 |
Zonisamide sodium
|
|
Others
|
|
Zonisamide sodium is a 1,2 benzisoxazole derivative. It is the first agent of this chemical class to be developed as an antiepileptic drug. |
|
T24958 |
(R)-Licarbazepine Acetate
|
BIA2-059,Licarbazepine acetate, (R)-,BIA 2-059,BIA-2-059 |
|
|
(R)-Licarbazepine Acetate is a hopeful antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine. |
|
T16869 |
Seletracetam
|
Ucb 44212 |
Others
|
|
Seletracetam is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy. |
|
T39708 |
Loreclezole hydrochloride
|
R 72063 hydrochloride,Loreclezole hydrochloride |
|
|
Loreclezole hydrochloride, an antiepileptic compound, functions as a selective modulator of GABA A receptors. Specifically, it acts as a positive allosteric modulator on receptors containing β2 or β3-subunits. |
|
T30748 |
Carisbamate
|
JNJ10234094,JNJ-10234094,RWJ 333369,RWJ-333369,RWJ333369 |
|
|
CarisbAMate (JNJ-10234094, RWJ 333369, YKP-509) is an antiepileptic drug candidate. |
|
TP1810 |
Somatostatin-25
|
|
|
|
Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic ... |
|
T39428 |
Seletracetam lithium bromide
|
Ucb 44212 lithium bromide |
|
|
Seletracetam (Ucb 44212) lithium bromide is a SV2A modulator, intended for epilepsy research. It is an analog of Levetiracetam, an antiepileptic agent. |
|
T13185 |
Topiramate D12
|
RWJ 17021 D12,McN 4853 D12 |
Others
|
|
Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor. |
|
T12544 |
Proglumide hemicalcium
|
|
Others
|
|
Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A/B receptors, has antiepileptic and antioxidant activities. |
|
T61145 |
Topiramate lithium
|
|
|
|
Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltag... |
|
T37149 |
Carbamazepine 10,11-epoxide
|
|
Others
|
|
Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e... |
|
T15818 |
LY367385
|
|
FXR
|
|
|
|
T61086 |
HN37
|
|
|
|
HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC 50 of 37 nM for KCNQ2 [1]. |
|
T16948 |
Suclofenide
|
PB385,Neosulfalepsine |
Others
|
|
Suclofenide is a benzenesulfonamide derivative that acts as an anticonvulsant and antiepileptic agent. In preclinical models, it showed potent anticonvulsant activity against electroshock and pentylenetetrazole-induced c... |
|
T75237 |
N3-[(Pyrid-4-yl)methyl]uridine
|
|
|
|
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, exhibits potential antiepileptic properties. Its analogs serve in researching anticonvulsant and anxiolytic effects, alongside facilitating the development of novel antih... |
|
T75233 |
N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine
|
|
|
|
N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine, a uridine analog, exhibits potential for antiepileptic effects. Its analogs hold promise for research into anticonvulsant and anxiolytic activ... |
|
T77991 |
Glutaurine TFA
|
Litoralon TFA |
|
|
Glutaurine (Litoralon) TFA, a compound featuring glutamine and taurine residues, functions as an orally active parathyroid hormone. Originating from the oxyphil cells of the parathyroid gland, this hormone is employed in... |
|
T75080 |
2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine
|
|
|
|
2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine, a uridine analogue, exhibits potential for antiepileptic applications. Its analogues serve in researching anticonvulsant and anxiolytic properties, and in the developmen... |
|
T75079 |
5’(R)-C-Methyl-5-fluorouridine
|
|
|
|
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties. Its analogues are instrumental in investigating anticonvulsant and anxiolytic effects and are pivotal in crafting novel an... |
|
T60492 |
Lamotrigine hydrate
|
|
|
|
Lamotrigine hydrate is an effective oral active anticonvulsant or antiepileptic agent that selectively blocks voltage-gated Na + channels, stabilizes presynaptic neuronal membranes and inhibits glutamate release. Lamotri... |
|
T75232 |
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine
|
|
|
|
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine, an analog of uridine known for its potential antiepileptic properties, is utilized in researching anticonvulsant and anxiolytic activities. Additionally, it aids in... |
|
T60355 |
LY367385 hydrochloride
|
|
|
|
LY367385 hydrochloride is a potent and selective mGluR1a antagonist with an IC50 value of 8.8 μM for inhibiting quisqualate-induced phosphoinositide (PI) hydrolysis, showing significantly higher selectivity compared to i... |
