Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IMD-0560 is a novel inhibitor of IκB kinase β.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 17,000 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 66,500 | |||
25 mg | 在庫あり | ¥ 112,000 | |||
50 mg | 在庫あり | ¥ 164,000 | |||
100 mg | 在庫あり | ¥ 226,500 |
説明 | IMD-0560 is a novel inhibitor of IκB kinase β. |
In vitro | IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. |
In vivo | Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group. |
分子量 | 428.12 |
分子式 | C15H8BrF6NO2 |
CAS No. | 439144-66-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 50 mg/mL (116.79 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IMD-0560 439144-66-8 NF-Κb IκB/IKK inhibit I kappa B kinase Inhibitor IMD 0560 IκB kinase IMD0560 IKK inhibitor