Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 21,000 | |||
50 mg | 在庫あり | ¥ 34,000 | |||
100 mg | 在庫あり | ¥ 64,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment. |
ターゲット&IC50 | Hec1:2.4 μM., NEK2:2.4 μM |
In vitro | INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis. [1] |
細胞研究 | Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.(Only for Reference) |
分子量 | 322.42 |
分子式 | C19H18N2OS |
CAS No. | 1001753-24-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 9 mg/mL (27.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (186.1 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
INH6 1001753-24-7 Apoptosis Cytoskeletal Signaling Microtubule Associated Inhibitor INH 6 inhibit INH-6 inhibitor