Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 17,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 60,500 | |||
25 mg | 在庫あり | ¥ 121,500 | |||
50 mg | 在庫あり | ¥ 176,500 | |||
100 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,500 |
説明 | IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor. |
ターゲット&IC50 | ETB:1.3 nM, ETA:94 nM |
In vivo | In the anesthetized rat, IRL 2500 (10 mg/kg; i.v.) decreases the IRL 1620-mediated enhances renal vascular resistance. IRL 2500 suppresses the initial transient reduction in mean arterial pressure induced by IRL 1620[1]. IRL 2500 (10 mg/kg; i.v.) pre-treatment reduces the initial vasodepressor response to endothelin-1 and IRL 1620 without altering the secondary and sustained pressor response[2]. |
分子量 | 573.68 |
分子式 | C36H35N3O4 |
CAS No. | 169545-27-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 93.6 mg/mL (163.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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IRL 2500 169545-27-1 GPCR/G Protein Endothelin Receptor IRL-2500 IRL2500 Inhibitor inhibitor inhibit