Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ibandronate sodium monohydrate (BM-210955) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
説明 | Ibandronate sodium monohydrate (BM-210955) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis. |
In vitro | Ibandronate (1.25–2 μM) significantly reduces endothelial cell growth, while ibandronate (2 μM) also significantly reduces capillary-like tube formation and increases apoptosis of endothelial cells. Ibandronate (< 100 μM) dose-dependently increases VEGF expression in endothelial cells. [1] Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner. [2] |
In vivo | Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduces the risk of new morphometric vertebral fractures by 62% and 50% (p = 0.0006), respectively, in osteoporotic women after 3 years' treatment. Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increases BMD of lumbar spine by 6.5% and 5.7%, respectively, in osteoporotic women after 3 years' treatment. [3] Ibandronate (< 125 mg/kg s.c.) results in a dose dependent increase in bone mineral density (BMD), trabecular bone volume and trabecular number, load to failure (Fmax), and yield load in long bones and vertebrae in ovariectomized rats, and increased trabecular separation in ovariectomized rats is fully prevented by all doses. [4] |
別名 | Boniva monohydrate, Bondronat monohydrate, Ibandronate sodium, BM-210955, BM-21.0955, RPR-102289A |
分子量 | 360.23 |
分子式 | C9H25NNaO8P2 |
CAS No. | 138926-19-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
You can also refer to dose conversion for different animals. 詳細
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Ibandronate sodium monohydrate 138926-19-9 Apoptosis Others Ibandronate sodium Monohydrate Inhibitor Boniva monohydrate Boniva Bondronat Bondronat monohydrate Ibandronate sodium BM 210955 inhibit BM210955 BM-210955 Boniva Monohydrate BM-21.0955 RPR-102289A Bondronat Monohydrate inhibitor