Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
説明 | Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor. |
ターゲット&IC50 | MMP1:0.4 nM(Ki), MMP2:0.5 nM(Ki), MMP26:0.36 nM(Ki), MMP9:0.2 nM(Ki), MMP8:0.1 nM(Ki) |
In vivo | Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. [3] In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates. [4] |
キナーゼ試験 | Collagenase assay uses the synthetic thiol ester substrate Ac-Pro-Leu-Gly-SCH(i-Bu)CO-Leu-Gly-OEt at pH 6.5. The collagenase concentration is 1-2 nM, and the substrate concentrations are from 0.1 to 0.7 nM. Km?is found to vary between 1.5 and 4 mM. |
別名 | Galardin, GM6001 |
分子量 | 388.46 |
分子式 | C20H28N4O4 |
CAS No. | 142880-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Ilomastat 142880-36-2 Proteases/Proteasome MMP Galardin GM-6001 GM 6001 inhibit Matrix metalloproteinases Inhibitor GM6001 inhibitor