Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-inflammatory effect.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 7,000 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-inflammatory effect. |
ターゲット&IC50 | COX-2:115 nM, COX-2(human):18 nM, COX-1:115 nM |
In vitro | In U937 cells, Imrecoxib (0.1-10 μM; 24 hours) reduces COX-2 mRNA level induced by PMA+LPS in a dose-dependent manner. |
In vivo | Imrecoxib (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling. It also inhibits heat-inactivated BCG induced-inflammtory polyarthritis. Imrecoxib (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) suppresses carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours. |
別名 | BAP-909 |
分子量 | 369.48 |
分子式 | C21H23NO3S |
CAS No. | 395683-14-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (243.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Imrecoxib 395683-14-4 Immunology/Inflammation Neuroscience COX Cyclooxygenase Inhibitor BAP-909 inhibit BAP 909 BAP909 inhibitor