Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
200 mg | 在庫あり | ¥ 7,500 | |||
500 mg | 在庫あり | ¥ 12,500 | |||
1 g | 在庫あり | ¥ 16,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,000 |
説明 | Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity. |
In vitro | Ivermectin exhibits antiviral activity against HIV-1 and Dengue fever virus. It binds to a novel site on GABAA receptors in hippocampal embryonic neurons of mice, conformationally enhancing the affinity of the GABA binding site. In nematodes, the compound interacts with glutamate-gated chloride channels (GluCls), disrupting the regulation mediated by GluCl activity. |
In vivo | Intraperitoneal injection of Ivermectin (1.25-10 mg/kg) can reduce the consumption of alcohol and saccharin. For mice exposed to lethal doses of LPS, Ivermectin inhibits LPS-induced NF-kB translocation and enhances survival rates. |
別名 | MK-933 |
分子量 | 875.09 |
分子式 | C48H74O14 |
CAS No. | 70288-86-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 27 mg/mL (30.9 mM)
DMSO: 93 mg/mL (106.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Ivermectin 70288-86-7 Autophagy Membrane transporter/Ion channel Microbiology/Virology Neuroscience Proteases/Proteasome Antibiotic HIV Protease HSV Parasite SARS-CoV GluCls P2X Receptor Mitophagy SARS coronavirus MK-933 inhibit MK933 Human immunodeficiency virus HIV Inhibitor Herpes simplex virus Mitochondrial Autophagy MK 933 inhibitor