Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
説明 | JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. |
ターゲット&IC50 | GHS-R1a:32±3 nM (in LLC-PK1 cells) |
In vitro | JMV 2959 does not induce any intracellular calcium mobilization by itself. The dissociation constant of the receptor/JMV 2959 complex is determined by the Schild method. This experiment reveals a dissociation constant Kb of 19±6 nM.JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. |
In vivo | Intraperitoneal (i.p.) administration of Ghrelin at doses of 0.033, 0.1, and 0.33 mg/kg has no significant effect on acoustic startle responses (ASR) or prepulse inhibition (PPI) in rats. In contrast, i.p. injection of JMV 2959 at 1, 3, and 6 mg/kg decreases ASR and enhances PPI in a dose-dependent manner. When administered at a dose that does not independently influence ASR or PPI, JMV 2959 effectively prevents deficits in PPI induced by Phencyclidine (PCP) at 2 mg/kg. However, pre-administration of the highest dose of Ghrelin does not modify the PPI responses to a sub-threshold dose of PCP (0.75 mg/kg). |
別名 | JMV 2959 hydrochloride |
分子量 | 545.08 |
分子式 | C30H33ClN6O2 |
CAS No. | 2448414-54-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (458.65 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JMV 2959 hydrochloride (925238-89-7 free base) 2448414-54-6 GPCR/G Protein GHSR JMV 2959 hydrochloride (925238897 free base) 925238-89-7 free base JMV 2959 hydrochloride 925238-89-7 JMV2959 Hydrochloride JMV 2959 hydrochloride (925238 89 7 free base) JMV 2959 Hydrochloride JMV-2959 Hydrochloride Inhibitor inhibitor inhibit