Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.
説明 | Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin. |
ターゲット&IC50 | Thiordoxine:10μM, Caspase-3:10μM |
In vitro | KEA1-97 (10 μM, 48h) impaired 231MFP cell survival and proliferation and does not affect viability in MCF10A cells. |
In vivo | KEA1–97 treatment (5 mg/kg ip once per day) was initiated 16 days after the initiation of 231MFP tumor xenografts in immune-deficient SCID mice. |
分子量 | 335.16 |
分子式 | C15H9Cl2FN4 |
CAS No. | 2138882-71-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL(268.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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KEA1-97 2138882-71-8 Apoptosis Others Proteases/Proteasome Caspase KEA1 97 Proliferation Apoptotic inhibit KEA-1-97 DCTalkyne 231MFP Inhibitor Selective KEA197 inhibitor