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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5831 | Selective PI3Kδ Inhibitor 1 | PI3K | |
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM). | |||
T80930 | TRPV2-selective blocker 1 | ||
TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM. It specifically targets the TRPV2 channel without impacting related TRPV1, TRPV3, or TRPV4 cha... | |||
T79184 | FKBP51F67V-selective antagonist Ligand2 | FKBP | |
FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or FKBP52 [1]. It effectively reverses the anxiogenic phenotype ... | |||
T16129 | MPI_5a | HDAC | |
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM). | |||
T19777 | ODQ | Apoptosis , Others , Guanylate cyclase | |
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor. | |||
T19891 | Metolachlor | Others | |
Metolachlor is an organic compound. Metolachlor is also widely used as an herbicide. | |||
T8485 | THIQ | Melanocortin Receptor | |
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). | |||
T8513 | Spastazoline | Others | |
Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ). | |||
T8580 | Bupranolol | Adrenergic Receptor | |
Bupranolol is an antagonist of β2-adrenergic receptor and has been used for angina pectoris, hypertension, glaucoma, cardiac arrhythmia and as an antithrombotic. | |||
T2430 | HPOB | Apoptosis , HDAC | |
T9925 | Ofatumumab | Others | |
Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation | |||
T22518 | 5-BDBD | P2X Receptor | |
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. | |||
T9118 | KEA1-97 | Apoptosis , Others , Caspase | |
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ... | |||
T15729 | LDN-91946 | DUB | |
T9570 | Enpatoran | TLR | |
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo. | |||
T7538 | Tetraethylammonium chloride | Potassium Channel | |
Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties. | |||
T7659 | Bisindolylmaleimide IV | Others , PKC | |
Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM) | |||
T9452 | PW0787 | GPR | |
PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). | |||
T22341 | GSK-114 | Others | |
GSK-114, a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM, shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral e... | |||
T3624 | A-366 | A 366,A366 | Epigenetic Reader Domain , Histone Methyltransferase |
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... | |||
T8535 | GAK inhibitor 49 | Serine/threonin kinase | |
GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ). | |||
T16745 | Rhosin hydrochloride | Apoptosis , Rho , Ras | |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... | |||
T9215 | ELOVL6-IN-2 | Others | |
ELOVL6-IN-2 is a orally active and selective ELOVL6 inhibitor. | |||
T2293 | SGX-523 | Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl | |
SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf. | |||
T8418 | DCLK1-IN-1 | Others | |
DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain . | |||
T11689 | ITI-214 | ITI214 | PDE |
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ... | |||
T22748 | DQP 1105 | NMDAR | |
DQP 1105 is a NMDA receptor antagonist. | |||
T2164 | Wiskostatin | Others | |
Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. | |||
T9214 | ELOVL6-IN-1 | Others | |
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner... | |||
T7149 | S29434 | NADPH , Autophagy | |
S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM). | |||
T11014 | DFP00173 | Aquaporin | |
T9194 | UMB298 | Epigenetic Reader Domain | |
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM. | |||
T3474 | RO 46-8443 | Endothelin Receptor | |
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. | |||
T38163 | ML-148 | Dehydrogenase | |
ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostagla... | |||
TP1898 | HS024 | HS 024 | Melanocortin Receptor |
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-... | |||
T4378 | MS049 | Histone Methyltransferase | |
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively. | |||
T11723L | JNJ-39758979 | Histamine Receptor | |
JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine... | |||
T9882 | RUVBL1/2 ATPase-IN-1 | Others | |
RUVBL1/2 ATPase-IN-1 is an effective RUVBL1/2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1/2 ATPase-IN-1 can be used in cancer disease studies. | |||
T5436 | MZ 1 | Epigenetic Reader Domain , PROTACs | |
MZ 1 is a BRD4 protein degrader based on PROTAC technology. | |||
T9164 | BMS-986242 | BMS986242 | IDO , Indoleamine 2,3-Dioxygenase (IDO) |
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer. | |||
T4534 | BMS-309403 | FABP | |
BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM. | |||
T8450 | TCN 213 | TCN213 | NMDAR |
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B | |||
T16143 | MRTX-1257 | Ras | |
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre... | |||
T7414 | ARS-853 | Apoptosis , Raf , Ras | |
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells | |||
T3072 | XL019 | Apoptosis , FLT , JAK , PDGFR | |
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1. | |||
T15784 | LP99 | Epigenetic Reader Domain | |
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9). | |||
T22514 | 4F 4PP oxalate | 5-HT Receptor | |
4F 4PP oxalate is a 5-HT2A antagonist. | |||
T3284 | Carazolol | Conducton,Suacron | Adrenergic Receptor |
Carazolol (Suacron) is a high-affinity antagonist/partial inverse agonist (also referred to as a beta blocker) of the β-adrenergic receptor. | |||
T6977 | SB-366791 | SB366791 | TRP/TRPV Channel |
SB-366791 is a new and selective cinnamide TRPV1 antagonist. | |||
T15032 | CYM50308 | S1P Receptor , LPL Receptor | |
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1120 | Osthenol | MAO , Monoamine Oxidase | |
Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activ... | |||
T9933 | Methyl 2,4-dihydroxyphenylacetate | Others | |
Methyl 2,4-dihydroxyphenylacetate is a natural product isolated from Nigella damascena seeds with selective phytotoxic effects. | |||
T5722 | Nevadensin | Pedunculin | Anti-infection , Antibacterial |
Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition acti... | |||
T15686 | L-741626 | 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole | Dopamine Receptor |
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). | |||
TQ0203 | Tafluprost | MK2452,AFP-168 | Prostaglandin Receptor |
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α. | |||
T8035 | 3'-Methoxyflavonol | NMU2R | |
3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R). | |||
TN1731 | Hernandezine | TNF , ROS , P-gp , AMPK | |
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells. | |||
T23306 | Salvinorin A | Opioid Receptor | |
Salvinorin A is a non-nitrogenous κ-opioid selective agonist. | |||
Fr12415 | Ethyl 4-hydroxyphenylacetate | Others | |
Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A. | |||
T5838 | L-Canavanine sulfate | NO Synthase , NOD | |
L-Canavanine sulfate is a selective inducible NO synthase inhibitor. | |||
T2266 | SantacruzaMate A | CAY-10683 | HDAC |
SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor. | |||
T13475 | β-Aminopropionitrile | 3-Aminopropionitrile,BAPN | Others , Endogenous Metabolite |
β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase. | |||
TN4171 | Grossamide | NO Synthase | |
Grossamide (GSE) Grossamide is a lignan amide derived from thioguanosine.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) i... | |||
T1680 | Tolazoline hydrochloride | Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride) | Adrenergic Receptor |
Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. | |||
T0453 | Phenylephrine hydrochloride | NCI-c55641,Phenylephrine HCl,(R)-(-)-Phenylephrine hydrochloride | Endogenous Metabolite , Adrenergic Receptor |
Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor. | |||
T3432 | Cinobufagin | Cinobufagine | Apoptosis , ATPase , Autophagy |
Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain. | |||
T6995 | Ochromycinone | STA 21,STA21,STA-21 | Antibacterial , STAT |
Ochromycinone (STA 21) is a selective STAT3 inhibitor. | |||
T8299 | Dimethyl lithospermate B | dmLSB | Sodium Channel |
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. | |||
TN2202 | Sempervirine | DNA/RNA Synthesis | |
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA . | |||
TMA1122 | N-Feruloylserotonin | (E/Z)-Moschamine,Moschamine | Antioxidant |
N-Feruloylserotonin ((E/Z)-Moschamine) is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. | |||
TQ0196 | Cucurbitacin I | NSC-521777,JSI-124,Elatericin B | JAK , STAT |
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity. | |||
T8187 | Tetrahydroepiberberine | Others , Influenza Virus , Antifungal | |
Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities. | |||
T17310 | Phenylephrine | L-Phenylephrine,(R)-(-)-Phenylephrine | Adrenergic Receptor |
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively). | |||
T8125 | Quinidine sulfate dihydrate | Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate | P450 |
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor | |||
T4643 | TFAP | N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide | COX , Endogenous Metabolite |
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor | |||
T1186 | Ifenprodil Tartrate | Potassium Channel , NMDAR , iGluR | |
Ifenprodil is a selective NMDA receptor (glutamate) antagonist. | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
T4S1521 | 1,4-Dicaffeoylquinic acid | HIV Protease | |
1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentration... | |||
TN1817 | Kaempferol 3,7,4'-trimethyl ether | Kaempferol 3,7,4'-trimethylether | NO Synthase |
Kaempferol 3,7,4'-trimethyl ether (Kaempferol 3,7,4'-trimethylether) shows selective cyctoxic activities against the nine tested cancer cell lines. | |||
T5743 | Gymnemagenin | Liver X Receptor | |
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity. | |||
TN2107 | Protoescigenin | Others | |
Protoescigenin is from horse chestnut saponin mixture and can be used as the substrate for exploratory chemistry towards selective protection. | |||
TN4618 | N-trans-Sinapoyltyramine | Others | |
N-trans-Sinapoyltyramine exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 9.77 ± 1.25 Μm. | |||
T7607 | PSI-6130 | R 1656 | HCV Protease |
PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM. | |||
T2922 | Phlorizin | Floridzin,NSC 2833,Phloridzin | ATPase , SGLT |
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . | |||
TN1490 | Chrysoeriol | ERK , p38 MAPK , Akt | |
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect. | |||
T21581L | AC 187 Acetate | AC 187 Acetate (151804-77-2 Free base) | Amylin Receptor |
AC 187 Acetate is a potent antagonist of amylin receptor .AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. | |||
TQ0288 | Hexahydrocurcumin | Reactive Oxygen Species , ROS , COX | |
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. | |||
T6648 | Rotundine | Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine | Dopamine Receptor , 5-HT Receptor |
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. | |||
T3325 | Liquiritigenin | 4',7-Dihydroxyflavanone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. | |||
T0505 | Methyldopa | L-(-)-α-Methyldopa,MK-351 | Dopamine Receptor , Adrenergic Receptor |
Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic. | |||
T6841 | Fumagillin | NSC9168,Amebacilin | Others , HIV Protease , Antibiotic , Parasite |
Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. | |||
T13469 | (±)-Huperzine A | AChE | |
(±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs. (±)-Huperzine A is a selective and reversible inhibitor of AChE and can be used in studies about the treatment of Alzheimer's dis... | |||
T8895 | Altenusin | FXR | |
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM. | |||
T17048 | Tetradecanoylcarnitine | L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine | Endogenous Metabolite |
Tetradecanoylcarnitine (L-Myristoylcarnitine) is an acylcarnitine involved in the beta-oxidation of long-chain fatty acids, and is a potential marker for very-long-chain coenzyme A dehydrogenase deficiency. alpha-Dihydro... | |||
TN6739 | Angoline | 6-Methoxyldihydrochelerythrine | IL Receptor , STAT |
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can... | |||
T1125 | Shikonin | NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid | TNF , NF-κB , Chloride channel , HIV Protease , PKM |
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities. | |||
TN2252 | Syrosingopine | Dopamine Receptor | |
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. | |||
T0906 | Salinomycin | Procoxacin | Wnt/beta-catenin , Antibacterial |
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph... | |||
T0167 | Vinpocetine | RGH-4405,Ethyl apovincaminate | IκB/IKK , NF-κB , Sodium Channel , PDE |
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). | |||
TN7121 | D-Epigalbacin | (-)-Zuonin A | JNK |
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-01068 | FKBP25/FKBP3 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif... | |||
TMPY-02292 | IGSF11 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins sh... | |||
TMPY-01460 | ABHD4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain... | |||
TMPH-03043 | PIA Protein, MenB, Recombinant (His) | MenB | E. coli |
Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity. | |||
TMPH-00107 | UBC10 Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | E. coli |
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC10 Protein, Arabidopsis thaliana, Recombinant... | |||
TMPY-04904 | Zika virus (ZIKV) (strain Zika SPH2015) M/Membrane protein (Fc) | ZIKV | HEK293 Cells |
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. ZIKV has a more selective and larger impact on the expression of genes involved in DNA replication and repair. P53 inhibit... | |||
TMPH-01693 | MAP3K14 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-ka... | |||
TMPH-00109 | UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc) | Arabidopsis thaliana | E. coli |
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC8 Protein, Arabidopsis thaliana, Recombinant ... | |||
TMPH-00108 | UBC11 Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | E. coli |
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC11 Protein, Arabidopsis thaliana, Recombinant... | |||
TMPJ-01221 | UBE2J2 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen... | |||
TMPH-03174 | LecA Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carb... | |||
TMPH-01816 | OX1R Protein, Human, Recombinant (His & SUMOstar) | Human | P. pastoris (Yeast) |
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. OX1R Protein, Human, Recombi... | |||
TMPH-00379 | MLCK Protein, Chicken, Recombinant (His & Myc & SUMO) | Chicken | E. coli |
Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. MLCK Protei... | |||
TMPK-00564 | TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of... | |||
TMPJ-00273 | IGSF11 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Immunoglobulin superfamily member 11(IGSF11) is abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.IGSF11 functions as a cell adhesion molecule through homophilic interact... | |||
TMPK-00394 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPH-01684 | MAP1LC3C Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p... | |||
TMPH-02905 | TRPC1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled recep... | |||
TMPK-00171 | TRAIL Trimer Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of... | |||
TMPK-00392 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPH-03606 | P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc) | Streptomyces | E. coli |
Dioxygenase that catalyzes the 2-oxoglutarate-dependent selective hydroxylation of free L-proline to cis-3-hydroxy-L-proline (cis-3-Hyp). D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline, cis-4-hydroxy-D-pro... | |||
TMPH-03390 | TRPV2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys... | |||
TMPH-02118 | SCN1A Protein, Human, Recombinant (His) | Human | E. coli |
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective chann... | |||
TMPY-05003 | GLTP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Glycolipid transfer proteins (GLTPs) originally were identified as small (~24 kDa), soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. Human GLTP-motifs have evolved to ... | |||
TMPJ-01363 | CLIC5 Protein, Human, Recombinant (His) | Human | E. coli |
Chloride Intracellular Channel Protein 5 (CLIC5) is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain. Chloride intracellular channels are involved in... | |||
TMPJ-00891 | Kallikrein 2/KLK2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave ... | |||
TMPH-02301 | VPS35 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transm... | |||
TMPH-02803 | NRROS Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPH-02347 | Influenza A H1N1 (strain A/USA:Phila/1935) Matrix protein 2 (His) | H1N1 | E. coli |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of th... | |||
TMPH-02365 | JC polyomavirus (JCV) Minor capsid protein VP2 (His) | JCPyV | E. coli |
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ... | |||
TMPH-00201 | BK polyomavirus (BKPyV) VP2 Protein (His) | BKPyV | E. coli |
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ... | |||
TMPY-01812 | Enoyl-ACP Reductase Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to theshort-chain dehydrogenases/reductases (SDR) family and FabI ... | |||
TMPH-02348 | Influenza A H1N1 (strain A/Puerto Rico/8/1934) Matrix protein 2 (His & Myc) | H1N1 | E. coli |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of th... | |||
TMPH-00789 | Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc) | HaPyV | E. coli |
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on... | |||
TMPH-01516 | FCGRT Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound... | |||
TMPY-02842 | UBE2L6 Protein, Human, Recombinant (His) | Human | E. coli |
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain.... | |||
TMPH-01517 | FCGRT Protein, Human, Recombinant (GST) | Human | E. coli |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound... | |||
TMPY-04554 | JNK1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellula... | |||
TMPJ-00782 | Amyloid Precursor Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and... | |||
TMPY-04402 | CSNK1G1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are ... | |||
TMPY-00564 | MCP-4 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family ... | |||
TMPH-00616 | DNA-binding protein H-NS Protein, E. coli, Recombinant (His) | E. coli | E. coli |
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstrea... | |||
TMPY-01187 | Rac1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L2010 | Highly Selective Inhibitor Library | 575 compounds | |
L9410 | Covalent Inhibitor Library | 1920 compounds | |
A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc. | |||
L7200 | Calcium Channel Compound Library | 140 compounds | |
A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening; | |||
L7400 | Sodium Channel Blocker Library | 118 compounds | |
A unique collection of 118 sodium channel blockers and agonists for high throughput and high content screening; | |||
L7300 | Potassium Channel Blocker Library | 152 compounds | |
A unique collection of 152 potassium channel blockers and agonists for high throughput and high content screening; | |||
L5900 | CNS-Penetrant Compound Library | 509 compounds | |
A unique collection of 509 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L2520 | Glycometabolism Compound Library | 702 compounds | |
702 glycometabolism-related comounds, can be used for HTS and HCT; |