Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 418,000 |
50 mg | 約8-10 週間 | ¥ 546,500 |
100 mg | 約8-10 週間 | ¥ 711,500 |
ターゲット&IC50 | A2A receptor:ki: 3.0 nM |
In vivo | Striatal uptake of [11C]KF21213 shows a gradual increase for the initial 15 minutes before declining, while its absorption by the cortex and cerebellum decreases swiftly post-injection, aligning with blood levels. As a result, the striatum to cortex and striatum to cerebellum uptake ratios escalate to 8.6±1.6 and 10.5±2.1 (N=4), respectively, within 60 minutes. Initially retained for 5 minutes, [11C]KF21213's striatal activity then diminishes over time, unlike [11C]KF18446, which drops quickly. Similarly, cerebellar activity for both ligands decreases rapidly. The striatum-to-cerebellum uptake ratio for [11C]KF21213 progressively increases to 2.4±0.5 (N=3) over 50-60 minutes, while for [11C]KF18446, it peaks within the first 10 minutes before stabilizing at 1.4±0.3 (N=3) between 25-35 minutes. |
分子量 | 354.4 |
分子式 | C19H22N4O3 |
CAS No. | 155271-17-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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KF21213 155271-17-3 Chromatin/Epigenetic Histone Demethylase KF-21213 KF 21213 Inhibitor inhibitor inhibit