Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
2 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 26,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 90,500 | |||
50 mg | 在庫あり | ¥ 142,000 | |||
100 mg | 在庫あり | ¥ 202,000 | |||
500 mg | 在庫あり | ¥ 411,000 |
説明 | RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM). |
ターゲット&IC50 | LSD1:70 nM, MAO-A:0.51 μM, MAO-B:2.785 μM |
In vitro | RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively[3]. |
In vivo | In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology[1]. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9[3]. |
分子量 | 452.42 |
分子式 | C23H31Cl2N3O2 |
CAS No. | 1781835-13-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 18 mg/mL (39.79 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RN-1 dihydrochloride 1781835-13-9 Chromatin/Epigenetic Metabolism Neuroscience Histone Demethylase MAO disease RN 1 dihydrochloride inhibit RN1 hemoglobin fetal RN1 dihydrochloride brain-penetrant LSD1 RN1 Dihydrochloride Inhibitor HbF sickle RN 1 Dihydrochloride cell irreversible RN 1 RN-1 RN-1 Dihydrochloride inhibitor