Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.
説明 | KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor. |
In vitro | In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain[1]. |
分子量 | 339.43 |
分子式 | C20H25N3O2 |
CAS No. | 796874-99-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (73.65 mM)
You can also refer to dose conversion for different animals. 詳細
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KYP-2047 796874-99-2 Others eNOS inhibit POP Neurotensin Angiopoietins MDM-2/p53 KYP 2047 prolyl oligopeptidase Glioblastoma VEGF KYP2047 Prolyl Endopeptidase (PREP) Inhibitor U-87 cell Apoptosis inhibitor