検索結果

Search Results for " MDM-2/p53 "

ターゲット

阻害剤

天然化合物

292

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T72771	p53 Activator 7		Apoptosis
	p53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2/p53), which induces apoptosis.		Apoptosis
T1887	Inauhzin	INZ	Sirtuin
	Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...		Sirtuin
T16523L	PhiKan 083		Mdm2
	PhiKan 083 is a carbazole derivative		Mdm2
T21578	NSC 66811		Mdm2
	NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53...		Mdm2
T1873	Tenovin-3	Tenovin3	Sirtuin
	Tenovin-3 acts as a p53 activator.		Sirtuin
T2464	ZMC1		p53
	NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).		p53
T7057	Methylstat		Histone Demethylase , Others
	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...		Histone Demethylase , Others
T6910	NSC59984		p53
	NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.		p53
T8774	MS7972		Epigenetic Reader Domain
	MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM		Epigenetic Reader Domain
T27029	Cjoc42	cjoc 42,cjoc-42
	Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w...
T6610	XI-006	NSC 207895	Mdm2 , p53
	XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.		Mdm2 , p53
T12257	NSC 146109 hydrochloride		Apoptosis , Others
			Apoptosis , Others
T9698	UC2288		Mdm2 , p53
	UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.		Mdm2 , p53
T7703	PK11007		Reactive Oxygen Species , p53
	PK11007 is an anti-p53 drug.		Reactive Oxygen Species , p53
T4325	COTI-2	COTI 2,COTI2	Apoptosis , p53
	COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.		Apoptosis , p53
T24730	Roslin 2 bromide	Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK , p53
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects.		FAK , p53
T21773	SP-141	SP 141	Mdm2
	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.		Mdm2
T1818	Tenovin-6	Tenovin 6	Dehydrogenase , Sirtuin , Autophagy
	Tenovin-6 is a p53 transcriptional activity agonist.		Dehydrogenase , Sirtuin , Autophagy
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T4414	Eprenetapopt	APR-246,PRIMA-1Met	Apoptosis , Others , Ferroptosis , p53 , Autophagy
	Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...		Apoptosis , Others , Ferroptosis , p53 , Autophagy
T8480	Tenovin-6 Hydrochloride		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
	Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
T1798	RITA	NSC 652287,RITA (NSC 652287)	Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
	RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.		Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
T6210	Pifithrin-μ	PFTμ,NSC 303580,2-Phenylethynesulfonamide	HSP , p53 , Autophagy
	Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.		HSP , p53 , Autophagy
T8657	KYP-2047		Others
	KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.		Others
T21648	CP-31398 dihydrochloride	CP 31398 dihydrochloride	p53
	CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.		p53
T12472	Pifithrin-α, p-Nitro, Cyclic	PFN-α	p53
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.		p53
T3289	Amifostine	Ethyol,WR2721,Gammaphos	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.		Others , HIF/HIF Prolyl-Hydroxylase
T2158	Nutlin-3	Nutlin3	E1/E2/E3 Enzyme
	Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.		E1/E2/E3 Enzyme
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T3517	RO8994		Mdm2 , E1/E2/E3 Enzyme , p53
	RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).		Mdm2 , E1/E2/E3 Enzyme , p53
T16888	SJ-172550		Mdm2 , E1/E2/E3 Enzyme
	SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).		Mdm2 , E1/E2/E3 Enzyme
T3653	MX69		Mdm2 , E1/E2/E3 Enzyme , IAP
	MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.		Mdm2 , E1/E2/E3 Enzyme , IAP
T6149	YH239-EE		Apoptosis , E1/E2/E3 Enzyme
	YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.		Apoptosis , E1/E2/E3 Enzyme
T22980	MIRA-1	p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis , p53
	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.		DNA/RNA Synthesis , p53
TQ0133	Amifostine thiol dihydrochloride	WR 1065	p53
	Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.		p53
T11980	MD-224		Mdm2 , E1/E2/E3 Enzyme , PROTACs
	MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.		Mdm2 , E1/E2/E3 Enzyme , PROTACs
T6381	Amifostine trihydrate	Ethyol trihydrate,WR2721,Amifostine	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.		Others , HIF/HIF Prolyl-Hydroxylase
T6023	Nutlin-3a	(-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis , E1/E2/E3 Enzyme , Autophagy
	Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.		Apoptosis , E1/E2/E3 Enzyme , Autophagy
T6954	PRIMA-1	2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1	Apoptosis , Others , Ferroptosis , Autophagy
	PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.		Apoptosis , Others , Ferroptosis , Autophagy
T1493	BH3I-1	BHI1	BCL , E1/E2/E3 Enzyme
	BH3I-1 (BHI1) is a Bcl-2 antagonist.		BCL , E1/E2/E3 Enzyme
T5555	Siremadlin	NVP-HDM 201	E1/E2/E3 Enzyme
	Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.		E1/E2/E3 Enzyme
T6254	Idasanutlin	RG7388,Ro 5503781	Mdm2 , E1/E2/E3 Enzyme
	Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).		Mdm2 , E1/E2/E3 Enzyme
T2243	Serdemetan	JNJ-26854165	Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
	Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.		Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
T6965	RG7112	RG-7112,RG 7112,RO5045337	Mdm2 , E1/E2/E3 Enzyme
	RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.		Mdm2 , E1/E2/E3 Enzyme
T24440	MDM2-p53-IN-1b	MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
	MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor.
TQ0231	NVP-CGM097	CGM097	Mdm2 , E1/E2/E3 Enzyme
	NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).		Mdm2 , E1/E2/E3 Enzyme
TQ0127	Navtemadlin	AMG232,CS-1300	Mdm2 , E1/E2/E3 Enzyme
	Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.		Mdm2 , E1/E2/E3 Enzyme
T3184	Kevetrin hydrochloride	Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2 , p53
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.		Mdm2 , p53
T6614	Nutlin-3b	(+)-Nutlin-3	Mdm2 , E1/E2/E3 Enzyme
	Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.		Mdm2 , E1/E2/E3 Enzyme
T6585	SAR405838	MI773,MI 773,MI-77301,MI-773	Mdm2 , E1/E2/E3 Enzyme
	MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.		Mdm2 , E1/E2/E3 Enzyme

Compounds

Target: Histone Demethylase, Others

Target: Epigenetic Reader Domain

cjoc42

T27029

Synonym: cjoc 42,cjoc-42

Target: Mdm2, p53

NSC 146109 hydrochloride

T12257

Synonym:

Target: Apoptosis, Others

UC2288

T9698

Synonym:

Target: Mdm2, p53

PK11007

T7703

Synonym:

Target: Reactive Oxygen Species, p53

COTI-2

T4325

Synonym: COTI 2,COTI2

Target: Apoptosis, p53

Roslin 2 bromide

T24730

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: Dehydrogenase, Sirtuin, Autophagy

Tenovin-1

T1919

Synonym: Tenovin 1

Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy

Eprenetapopt

T4414

Synonym: APR-246,PRIMA-1Met

Target: Apoptosis, Others, Ferroptosis, p53, Autophagy

Tenovin-6 Hydrochloride

T8480

Synonym:

Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy

RITA

T1798

Synonym: NSC 652287,RITA (NSC 652287)

Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy

Pifithrin-μ

T6210

Synonym: PFTμ,NSC 303580,2-Phenylethynesulfonamide

Target: HSP, p53, Autophagy

CP-31398 dihydrochloride

T21648

Synonym: CP 31398 dihydrochloride

Target: p53

Pifithrin-α, p-Nitro, Cyclic

Synonym: Ethyol,WR2721,Gammaphos

Target: Others, HIF/HIF Prolyl-Hydroxylase

Nutlin-3

T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

PK11000

T4459

Synonym:

Target: DNA Alkylator/Crosslinker

RO8994

T3517

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme, p53

SJ-172550

T16888

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme

MX69

T3653

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme, IAP

YH239-EE

T6149

Synonym:

Target: Apoptosis, E1/E2/E3 Enzyme

MIRA-1

T22980

Synonym: p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor

Target: DNA/RNA Synthesis, p53

Amifostine thiol dihydrochloride

Target: Mdm2, E1/E2/E3 Enzyme, PROTACs

Amifostine trihydrate

T6381

Synonym: Ethyol trihydrate,WR2721,Amifostine

Target: Others, HIF/HIF Prolyl-Hydroxylase

Nutlin-3a

T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

PRIMA-1

T6954

Synonym: 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1

Target: Apoptosis, Others, Ferroptosis, Autophagy

BH3I-1

T1493

Synonym: BHI1

Target: BCL, E1/E2/E3 Enzyme

Siremadlin

T5555

Synonym: NVP-HDM 201

Target: E1/E2/E3 Enzyme

Idasanutlin

T6254

Synonym: RG7388,Ro 5503781

Target: Mdm2, E1/E2/E3 Enzyme

Serdemetan

T2243

Synonym: JNJ-26854165

Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53

RG7112

T6965

Synonym: RG-7112,RG 7112,RO5045337

Target: Mdm2, E1/E2/E3 Enzyme

MDM2-p53-IN-1b

T24440

Synonym: MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b

Target: Mdm2, E1/E2/E3 Enzyme

Navtemadlin

TQ0127

Synonym: AMG232,CS-1300

Target: Mdm2, E1/E2/E3 Enzyme

Kevetrin hydrochloride

T3184

Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride

Target: Mdm2, p53

Nutlin-3b

T6614

Synonym: (+)-Nutlin-3

Target: Mdm2, E1/E2/E3 Enzyme

SAR405838

T6585

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

カタログ番号	製品名	別名	ターゲット
T4036	Solasodine	Solancarpidine,Purapuridine,Solasodin	Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
	Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...		Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
T3798	Ziyuglycoside I	Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H	Apoptosis , Others
	Ziyuglycoside I (Gouguside 7) has anti-inflammatory activity, could be used as an active ingredient for cosmetics.		Apoptosis , Others

天然物製品

Solasodine

T4036

Synonym: Solancarpidine,Purapuridine,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Ziyuglycoside I

T3798

Synonym: Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H

Target: Apoptosis, Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-00850	ST2/IL-1 RL1 Protein, Human, Recombinant	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-02358	CD98 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr...
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293
	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149)	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli.
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00871	LAYN Protein, Human, Recombinant (hFc)	Human	HEK293
	Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet...
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-00849	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-04844	BTN3A1 Protein, Human, Recombinant (His)	Human	HEK293
	BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmemb...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc)	Human	HEK293
	CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is ...
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a)	Human	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-05427	CD19 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01199	CD74 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-02367	Neuropilin-1 Protein, Human, Recombinant (isoform b, His)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-01935	C-Kit Protein, Human, Recombinant (His)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-02096	TACI Protein, Human, Recombinant (His)	Human	HEK293
	Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF...
TMPY-01359	ST2/IL-1 RL1 Protein, Human, Recombinant (His)	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-01985	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 cells.
TMPJ-00335	TGFBR2 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPY-04829	G-CSF Protein, Human, Recombinant	Human	HEK293
	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-04644	PDGFB Protein, Human, Recombinant (His)	Human	Yeast
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-01871	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)	Human	HEK293
	Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine recept...
TMPY-05414	NKG2D/CD314 Protein, Mouse, Recombinant (hFc)	Mouse	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-02231	TrkB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-01442	DMBT1 Protein, Human, Recombinant (His)	Human	HEK293
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d...
TMPY-00747	Nectin-2 Protein, Human, Recombinant (His)	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-02500	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC c...
TMPY-03425	Tau Protein, Human, Recombinant (His)	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are...
TMPY-02432	VEGF164 Protein, Rat, Recombinant	Rat	Baculovirus-Insect Cells
	Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-01717	VEGF164 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-04051	C-Kit Protein, Human, Recombinant (hFc)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-00392	PAM Protein, Human, Recombinant (His)	Human	HEK293
	Peptidylglycine alpha-amidating monooxygenase (PAM) is highly expressed in neurons and endocrine cells, where it catalyzes one of the final steps in the biosynthesis of bioactive peptides. PAM is also expressed in unicel...
TMPK-00699	FAM19A5 Protein, Human, Recombinant (His)	Human	E. coli
	FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available ...
TMPK-00696	PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)	Human	Baculovirus-Insect Cells
	The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-...
TMPK-00960	MSLN/Mesothelin Protein, Human, Recombinant (His & Avi), PE-Labeled	Human	HEK293
	Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached ...
TMPY-06822	Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent	Human	HEK293
	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
------------------------ More ------------------------