Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 在庫あり | ¥ 9,000 |
5 mg | 在庫あり | ¥ 11,000 |
10 mg | 在庫あり | ¥ 20,000 |
25 mg | 在庫あり | ¥ 40,000 |
50 mg | お問い合わせ | ¥ 59,000 |
100 mg | お問い合わせ | ¥ 87,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 21,500 |
説明 | LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM. |
ターゲット&IC50 | CDK9:44±10 nM |
In vitro | LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo?RNA synthesis of cellular genes.[1] |
キナーゼ試験 | The fluorescence resonance energy transfer (FRET)-based LANCE Ultra KinaSelect Ser/Thr kit is used to determine IC50 values for various CDK inhibitors. Briefly, a specific ULight MBP peptide substrate (50 nM final concentration) is phosphorylated by a CDK-cyclin pair in buffer (50 mM HEPES-KOH pH 7.5, 10 mM MgCl2, 1 mM EGTA, 2 mM dithiothreitol) containing ATP at the concentration of the Km values of the individual kinases for 1 h at room temperature. Subsequently, phosphorylation is detected by addition of specific Eu-labelled anti-phospho-antibodies (2 nM), which upon binding to the phosphopeptide give rise to a FRET signal. FRET signals are then recorded[1]. |
別名 | LDC067 |
分子量 | 370.43 |
分子式 | C18H18N4O3S |
CAS No. | 1073485-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (186.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LDC000067 1073485-20-7 Apoptosis Cell Cycle/Checkpoint CDK LDC067 LDC 067 LDC-000067 Cyclin dependent kinase LDC 000067 inhibit Inhibitor LDC-067 inhibitor