Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM).
説明 | LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM). |
ターゲット&IC50 | BIKE:14 nM, AAK1:0.9 nM(Ki), AAK1:3.3 nM, GAK:320 nM |
分子量 | 396.44 |
分子式 | C20H24N6O3 |
CAS No. | 1454555-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 175 mg/mL (441.43 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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LP-935509 1454555-29-3 Cell Cycle/Checkpoint Metabolism Neuroscience Serine/threonin kinase AAK1 (AP2 associated kinase 1) orally active AP2-associated kinase 1 Inhibitor brain-penetrant SARS coronavirus LP 935509 pain spinal nerve ligation SARS-CoV Cyclin G-associated Kinase (GAK) Antinociceptive AAK1 LP935509 infection chronic constriction injury inhibit streptozotocin formalin Auxilin 2 ATP-competitive SNL Adaptor-associated Kinase 1 inhibitor