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T12885 |
SGC-AAK1-1
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AAK1 (AP2 associated kinase 1)
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SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe. |
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T5093 |
Pim1/AKK1-IN-1
|
LKB1/AAK1 dual inhibitor,MDK-2275 |
Pim
,
Hippo pathway
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Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. |
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T34630 |
SGC-AAK1-1N
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SGCAAK11N,SGCAAK1-1N,SGC-AAK11N |
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SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) with an IC 50 of 1.8 μM [1]. |
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T61693 |
AAK1-IN-5
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AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivit... |
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T60829 |
AAK1-IN-3
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AAK1-IN-3 is a quinoline analogue that can be used in the research of neuropathic pain. AAK1-IN-3 is a brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) (IC 50 = 11 nM) [1]. |
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T61499 |
AAK1-IN-4
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AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degr... |
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T63833 |
AAK1-IN-2 TFA
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AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier. |
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T60828 |
AAK1-IN-2
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AAK1-IN-2 (compound (S)-31) can be used in neuropathic pain research that is a potent, selective and brain-penetrant Adaptor Protein 2-Associated Kinase 1(AAK1) inhibitor (IC 50 = 5.8 nM) [1]. |
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T63834 |
AAK1-IN-3 TFA
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AAK1-IN-3 TFA is an adaptor protein 2-associated kinase 1 (AAK1) inhibitor (IC50: 11 nM) that crosses the blood-brain barrier and is a quinoline analogue.AAK1-IN-3 has shown potential for research in neuropathic pain. |
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T35856 |
BMS-986176
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AAK1 (AP2 associated kinase 1)
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AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1].
Adaptor associated kinase 1 (AAK1) is a member of the A... |
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T15781 |
LP-935509
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Serine/threonin kinase
,
AAK1 (AP2 associated kinase 1)
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LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-... |
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T15780 |
LP-922761
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AAK1 (AP2 associated kinase 1)
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LP-922761 is a potent, selective, and orally active AAK1 inhibitor with inhibitory effects on BMP-2 induced protein kinase (BIKE). |
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T10572 |
BMT-124110
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AAK1 (AP2 associated kinase 1)
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BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM. BMT-090605 inhibits cyclin G-associated kinase GAK with an... |
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T10572L |
BMT-124110 Formate
|
BMT-124110 Formate（1679371-59-5 Free base） |
Serine/threonin kinase
,
TGF-beta/Smad
,
AAK1 (AP2 associated kinase 1)
|
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BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the ce... |
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T36680 |
SM1-71
|
|
Serine/threonin kinase
,
MAPK
,
LIM Kinase
,
TGF-beta/Smad
,
AAK1 (AP2 associated kinase 1)
|
|
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-7... |
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T10571 |
BMS-901715
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|
Others
|
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BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM). |
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T77333L |
(Iso)-BMT-124110 Formate
|
(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base） |
AAK1 (AP2 associated kinase 1)
|
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(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease. |
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T70459 |
BMT-046091
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BMT-046091 is a potent and selective radioligand which inhibits adaptor-associated kinase 1 (AAK1). |
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T30543 |
BMS-911172
|
BMS911172,BMS 911172 |
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BMS-911172 is an adaptor associated kinase 1 (AAK1 kinase) inhibitor with an IC 50 of 35 nM. |
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T14691 |
BMT-090605
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Others
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BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-09... |
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T61941 |
BMT-090605 hydrochloride
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BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-rel... |
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T82385 |
FMF-06-098-1
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|
PROTACs
|
|
FMF-06-098-1 is a multitargeted depressant capable of promoting the degradation of a wide array of kinases, including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D... |
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T62143 |
LP-922761 hydrate
|
|
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LP-922761 hydrate is a selective, potent, orally active AAK1 inhibitor with IC50 values of 4.8 nM and 7.6 nM in enzyme and cellular assays, respectively. LP-922761 hydrate inhibits BMP-2 inducible protein kinase (BIKE) (... |
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T74644 |
DB0614
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PROTACs
|
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DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK... |
