Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation of p65 mediated by TNF-α receptor, but inhibits the nuclear translocation of p52 stimulated by TWEAK or Anti-LTβR. Translocation with IC50 of 10 μM. LTβR-IN-1 regulates the NF-kB signaling pathway through a ligand-independent manner.
説明 | LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation of p65 mediated by TNF-α receptor, but inhibits the nuclear translocation of p52 stimulated by TWEAK or Anti-LTβR. Translocation with IC50 of 10 μM. LTβR-IN-1 regulates the NF-kB signaling pathway through a ligand-independent manner. |
ターゲット&IC50 | LTβR (p52 translocation):10 μM , LTβR (p52 translocation):0.169 μM |
分子量 | 320.35 |
分子式 | C18H16N4O2 |
CAS No. | 2189366-77-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 113 mg/mL (350 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LTβR-IN-1 2189366-77-4 Immunology/Inflammation NF-Κb Others NF-κB LTR LTβR IN 1 LTbetaR-IN-1 LTbR-IN-1 LTβRIN1 Inhibitor inhibitor inhibit