Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,500 | |||
5 mg | 在庫あり | ¥ 68,000 | |||
10 mg | 在庫あり | ¥ 108,500 | |||
25 mg | 在庫あり | ¥ 174,000 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
100 mg | 在庫あり | ¥ 317,000 | |||
500 mg | 在庫あり | ¥ 640,500 |
説明 | LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM. |
ターゲット&IC50 | mGlu1:0.145 μM, EGFR:0.91 μM |
In vitro | LY456236 (2 μM; 30 min) reduces the proliferation of OCCM-30 cells stimulated by DHPG .[1] |
In vivo | LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).[2] |
別名 | MPMQ hydrochloride |
分子量 | 317.77 |
分子式 | C16H16ClN3O2 |
CAS No. | 338736-46-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (708.1 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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LY 456236 hydrochloride 338736-46-2 Angiogenesis JAK/STAT signaling Neuroscience Tyrosine Kinase/Adaptors EGFR GluR MPMQ hydrochloride LY 456236 Hydrochloride LY-456236 Hydrochloride MPMQ Hydrochloride LY456236 Hydrochloride Inhibitor inhibitor inhibit