Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.
説明 | LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor. |
In vitro | LY-402913 inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC50=0.90 μM), while showing no inherent cytotoxicity. LY-402913 inhibits ATP-dependent, MRP1-mediated LTC4 uptake into membrane vesicles prepared from the MRP1-overexpressing HeLa-T5 cells (EC50=1.8 μM). LY-402913 also shows selectivity (∼22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells[2]. |
In vivo | When dosed in combination with the oncolytic MRP1 substrate vincristine, LY-402913 delays the growth of MRP1-overexpressing tumors in vivo[2]. |
別名 | LY 402913, LY402913 |
分子量 | 533.96 |
分子式 | C28H24ClN3O6 |
CAS No. | 334970-65-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (93.64 mM)
You can also refer to dose conversion for different animals. 詳細
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LY-402913 334970-65-9 Immunology/Inflammation MRP LY 402913 LY402913 Inhibitor inhibitor inhibit