Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,500 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
25 mg | 在庫あり | ¥ 34,000 | |||
100 mg | 在庫あり | ¥ 88,000 | |||
200 mg | 在庫あり | ¥ 133,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. |
ターゲット&IC50 | 5-HT1D:249 nM(Ki) |
In vitro | Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group. |
In vivo | LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. |
別名 | LY310762 HCl |
分子量 | 430.94 |
分子式 | C24H27FN2O2·HCl |
CAS No. | 192927-92-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43.1 mg/mL (100 mM)
H2O: 4.3 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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LY310762 192927-92-7 GPCR/G Protein Neuroscience 5-HT Receptor LY-310762 5-hydroxytryptamine Receptor Inhibitor Serotonin Receptor LY310762 HCl inhibit LY 310762 inhibitor