Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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500 mg | 在庫あり | ¥ 10,500 | |||
1 g | 在庫あり | ¥ 13,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil. |
ターゲット&IC50 | S. epidermidis:4 μg/mL(EC50), P. acnes:2μg/mL(EC50), S. aureus:6μg/mL(EC50) |
In vitro | Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS[1]. |
キナーゼ試験 | JAK2 and other human kinase activity assays: JAK2 kinase activity was assessed with the HTScan JAK2 Kinase Assay Kit per manufacturer's protocol. The possible effects of FLLL32 on the other 10 purified human protein kinases were determined by using a Kinase Profiler Assay. |
細胞研究 | Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 105 and 1.5 × 105 cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO2 and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate. (Only for Reference) |
植物由来 |
別名 | Dodecylic acid, dodecanoic acid, Vulvic acid, N-Dodecanoic acid |
分子量 | 200.32 |
分子式 | C12H24O2 |
CAS No. | 143-07-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 38 mg/mL (189.7 mM)
DMSO: 45 mg/mL (224.64 mM)
H2O: 16 mg/mL (79.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Lauric Acid 143-07-7 Metabolism Microbiology/Virology Others Antibacterial Endogenous Metabolite Inhibitor Dodecylic acid Bacterial dodecanoic acid inhibit Vulvic acid N-Dodecanoic acid inhibitor