Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 29,500 |
5 mg | 在庫あり | ¥ 66,500 |
10 mg | 在庫あり | ¥ 114,000 |
25 mg | 在庫あり | ¥ 182,000 |
50 mg | お問い合わせ | ¥ 248,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 78,000 |
説明 | Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. |
ターゲット&IC50 | HepG2 cells:3.4microg/ml |
In vitro | In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1] |
In vivo | Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1]. |
植物由来 |
別名 | Isokurarinone |
分子量 | 438.51 |
分子式 | C26H30O6 |
CAS No. | 97938-31-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/ml (171.03 mM)
You can also refer to dose conversion for different animals. 詳細
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Leachianone A 97938-31-3 GPCR/G Protein SGLT Apoptosis Isokurarinone Inhibitor inhibit inhibitor