Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,500 | |||
25 mg | 在庫あり | ¥ 35,500 | |||
50 mg | 在庫あり | ¥ 57,000 | |||
100 mg | 在庫あり | ¥ 85,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | 1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin. |
植物由来 |
別名 | Buddleoflavonoloside, Buddleoside, Acacetin-7-O-rutinoside, Acaciin, Linarine |
分子量 | 592.55 |
分子式 | C28H32O14 |
CAS No. | 480-36-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyridine, Methanol, etc.: Soluble
DMSO: 91 mg/mL(153.6 mM)
Ethanol: Soluble
You can also refer to dose conversion for different animals. 詳細
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Linarin 480-36-4 Apoptosis Neuroscience TNF AChE arvensis Buddleoflavonoloside Buddleoside Inhibitor acetylcholinesterase inhibit Acacetin-7-O-rutinoside Mentha Acaciin Linarine Cholinesterase (ChE) inhibitor