Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 56,000 | |||
10 mg | 在庫あり | ¥ 93,000 | |||
25 mg | 在庫あり | ¥ 155,500 | |||
50 mg | 在庫あり | ¥ 221,000 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 62,500 |
説明 | UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer. |
In vitro | In Hek-293 cells, UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202?nM after TNF (10?pM) stimulation. UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116?nM and a geometric mean IC50?of 120?nM, using human and mouse TNF, respectively. |
In vivo | UCB-9260 (150?mg/kg; p.o.) treatment twice daily?for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment. |
分子量 | 423.51 |
分子式 | C26H25N5O |
CAS No. | 1515888-53-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.23 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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UCB-9260 1515888-53-5 Apoptosis TNF cytotoxicity asymmetric trimer Inhibitor neutrophil autoimmune UCB9260 Tumor Necrosis Factor Receptor TNFR rheumatoid UCB 9260 arthritis inhibit TNF Receptor cytokine selective inhibitor