Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lisinopril dihydrate (MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
500 mg | 在庫あり | ¥ 13,000 | |||
1 g | 在庫あり | ¥ 21,000 | |||
1 mL * 10 mM (in H2O) | 在庫あり | ¥ 17,000 |
説明 | Lisinopril dihydrate (MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
In vitro | Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. [1] Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. [2] |
In vivo | Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. [3] Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. [4] Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. [5] Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. [6] |
別名 | Lisinopril, Renacor, MK-521 (dihydrate) |
分子量 | 441.52 |
分子式 | C21H35N3O7 |
CAS No. | 83915-83-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
You can also refer to dose conversion for different animals. 詳細
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Lisinopril dihydrate 83915-83-7 Endocrinology/Hormones Immunology/Inflammation RAAS MRP Inhibitor inhibit Lisinopril MK521 Angiotensin-converting Enzyme (ACE) MK-521 dihydrate Renacor MK-521 Lisinopril Dihydrate MK 521 MK-521 (dihydrate) inhibitor