Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Losartan potassium (DuP-753 potassium) , an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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500 mg | 在庫あり | ¥ 10,500 | |||
1 g | 在庫あり | ¥ 12,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Losartan potassium (DuP-753 potassium) , an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. |
ターゲット&IC50 | AT1 receptor:20 nM |
In vitro | Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM[1]. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC[2]. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone[3]. |
細胞研究 | An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival. |
別名 | DuP-753 potassium, MK 954, DuP 753 |
分子量 | 461.01 |
分子式 | C22H22ClKN6O |
CAS No. | 124750-99-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 46.1 mg/mL (100 mM)
DMSO: 55 mg/mL (119.3 mM)
You can also refer to dose conversion for different animals. 詳細
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Losartan potassium 124750-99-8 Endocrinology/Hormones RAAS Angiotensin Receptor MK954 inhibit Losartan DuP-753 potassium DuP-753 MK 954 DuP753 DuP 753 MK-954 Inhibitor inhibitor