Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .
説明 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) . |
ターゲット&IC50 | LRH1:3.7 µM (IC50) |
In vitro | ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling[2]. |
In vivo | ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2]. |
別名 | SR1848 |
分子量 | 388.89 |
分子式 | C20H25ClN4O2 |
CAS No. | 863588-32-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (28.28 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ML-180 863588-32-3 Others SR-1848 SR1848 steroidogenic Inhibitor Orphan factor-1 LRH-1 cancers nuclear NR5A2 NR5A1 inhibit homolog liver ML180 SR 1848 receptor ML 180 SF-1 inhibitor