598
207
707
8
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T80055 | Beta-glucuronidase (bovine liver) | ||
Beta-glucuronidase, a critical lysosomal enzyme, is implicated in the breakdown of glucuronate-containing glycosaminoglycans [1]. | |||
T81944 | LEAP-2 | Human liver expressed antimicrobial peptide-2 | |
LEAP-2 (Liver-expressed antimicrobial peptide 2) is a peptide of human origin with antimicrobial properties, initially identified in blood [1]. | |||
T1801 | SR9243 | Liver X Receptor | |
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect. | |||
T16930 | SR9238 | Liver X Receptor | |
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). | |||
T15427 | GSK2033 | Liver X Receptor | |
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively). | |||
T5178 | AZ876 | Liver X Receptor | |
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. | |||
T6347 | Ki16198 | LPA Receptor , LPL Receptor | |
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ... | |||
T11991 | Mefentrifluconazole | P450 , Antifungal | |
Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ... | |||
T12580 | PTUPB | COX , Epoxide Hydrolase | |
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively). | |||
T9215 | ELOVL6-IN-2 | Others | |
ELOVL6-IN-2 is a orally active and selective ELOVL6 inhibitor. | |||
T11428 | Glyco-Obeticholic acid | FXR | |
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR). | |||
T2601 | Vidofludimus | SC12267,4sc-101 | Dehydrogenase , DNA/RNA Synthesis , Interleukin |
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). | |||
T3633 | Crenigacestat | LY3039478 | Gamma-secretase |
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... | |||
T15371 | Gardiquimod | TLR , HIV Protease | |
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells... | |||
T10904 | CWP232228 | Wnt/beta-catenin | |
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... | |||
T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T7768 | RGX-104 | RGX-104 free Acid | Liver X Receptor |
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) | |||
T1115 | Doxylamine succinate | Decapryn | Histamine Receptor |
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... | |||
T0456 | Cinchophen | Cinconal | COX |
Cinchophen (Cinconal), an analgesic drug, is utilized in treating gout. | |||
T5421 | KDU691 | Parasite , PI4K | |
KDU691 is a PI4K inhibitor. | |||
T6031 | GNE0877 | GNE 0877,GNE-0877 | LRRK2 |
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). | |||
T1783 | LXR-623 | LXR623,WAY 252623 | Liver X Receptor |
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. | |||
TP2333 | Cyclo(L-Pro-L-Tyr) | Others | |
Maculosin is a secondary metabolite of fungi and bacteria. | |||
T6310 | GW3965 hydrochloride | GW3965 HCl | Liver X Receptor |
GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM). | |||
T19399 | L-Ornithine L-aspartate | Ornithine Aspartate | Others |
L-Ornithine L-aspartate (Ornithine Aspartate) lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. | |||
T1677 | Montelukast | Singular | Leukotriene Receptor , Lipoxygenase , LTR |
Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury... | |||
T3053 | CZC-25146 | CHEMBL2397014 | LRRK2 |
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively. | |||
T5139 | CZC-25146 hydrochloride | LRRK2 | |
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively. | |||
T1677L | Montelukast sodium | MK0476 | Leukotriene Receptor , LTR |
Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver i... | |||
T8526 | Metformin | 1,1-Dimethylbiguanide | Mitophagy , AMPK , Autophagy |
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm... | |||
T12075 | ML-180 | SR1848 | Others |
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) . | |||
T22323 | Enoxaparin sodium | Thrombin | |
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu... | |||
T4190 | Ticlopidine | PCR 5332,Ticlid | ATPase , Adiponectin receptor |
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. | |||
T5128 | RGX-104 hydrochloride | SB742881,RGX-104 HCl | Liver X Receptor |
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene. | |||
T2171 | SEW2871 | SEW2871 | S1P Receptor , LPL Receptor |
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... | |||
T12883 | Fezagepras | PBI-4050,Setogepram | GPR |
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. | |||
T8505 | SC-236 | Sc 236 | Apoptosis , COX , PPAR |
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). | |||
T8364 | Mebrofenin | SQ 26962 | Others |
Mebrofenin (SQ 26962) is available as a ready to use the kit for radio-labeling with Tc-99m.Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to... | |||
T8845 | UTL-5g | 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g | TNF |
UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hemat... | |||
T1090 | Perphenazine | Perphenazin,Etaperazine,Trilafon | CaMK , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor |
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. | |||
T6714 | URB-597 | KDS-4103,FAAH Inhibitor II | Mitophagy , FAAH , Autophagy |
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. | |||
T22443 | Triglycidyl isocyanurate | Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI | Apoptosis |
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk... | |||
T3970 | BMS-779788 | XL652,EXEL04286652,XL 652,XL-652,BMS-788 | Liver X Receptor |
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). | |||
T3424 | Ezutromid | BMN 195,VOX-C1100,SMT C1100 | Others |
Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ... | |||
T9010 | IMM-H007 | Others , AMPK | |
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression | |||
T0740 | Metformin hydrochloride | Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride | Mitophagy , AMPK , Autophagy |
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro... | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T1406 | Amantadine hydrochloride | 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride | Dopamine Receptor , Influenza Virus |
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease. | |||
T19526 | Pradefovir mesylate | Pradefovir mesilate,Remofovir mesylate,Hepavir B | P450 |
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM. | |||
T11024 | DHODH-IN-15 | Dehydrogenase | |
DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8254 | Chrysoobtusin | Others | |
Chrysoobtusin belongs to the class of organic compounds known as hydroxyanthraquinones. | |||
T7529 | Yamogenin | Others | |
Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek. | |||
T13092 | Tauro-Obeticholic acid | FXR | |
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). | |||
T2768 | Saikosaponin A | NF-κB , Antibacterial , Liver X Receptor | |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
T5613 | Squalane | Dodecahydrosqualene,Perhydrosqualene | Others |
Squalane (Perhydrosqualene) is a naturally occurring lipid in both plants and animals. It is usually used as a moisturizer and emollient in cosmetics manufacturing. | |||
T8733 | Antrodin A | camphorataanhydride A | Others |
Antrodin A (camphorataanhydride A) (AdA) is one of the main active ingredients in the solid-state fermented A. camphorata mycelium. It protects the liver from alcohol damage by improving the antioxidant and anti-inflamma... | |||
T8117 | Metenolone acetate | Methenolone acetate | Others , Androgen Receptor |
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. | |||
T13741 | Isoviolanthin | Others | |
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat... | |||
T5S1923 | Schisandrin C | Schizandrin-C,Wuweizisu-C | Apoptosis , Others , Virus Protease |
Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells. | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
T2810 | (20S)-Protopanaxatriol | 20(S)-APPT,g-PPT | Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor |
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. | |||
T3999 | D(+)-Galactosamine hydrochloride | D-Galactosamine HCl | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. | |||
T3673 | Mollugin | Rubimaillin | HER , JAK |
Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr... | |||
T3324 | Lycorine | Galanthidine,Narcissine,Amarylline,Belamarine,Licorine | Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase |
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive. | |||
T7060 | Amantadine | 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine | Others |
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. | |||
T7475 | S-Adenosyl-L-methionine | AdoMet,Ademetionine,SAMe,S-Adenosyl methionine | Others , Endogenous Metabolite |
S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder. | |||
T35981 | Biliverdin hydrochloride | Antioxidant | |
Biliverdin hydrochloride is a tetrapyrrole water-soluble compound formed from the oxidation of heme, with potential antioxidant activity, involved in the biliverdin-bilirubin redox system. | |||
TN1599 | Eburicoic acid | Eburicoicacid,MFCD00238594,ZINC4655149 | Antioxidant , TNF , NOS , NO Synthase , CCR , Immunology/Inflammation related |
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer. | |||
TQ0226 | Jionoside B1 | Others | |
Jionoside B1 has immunosuppressive activity and shows the hepato-protective activity in the H2O2 induced liver injury experiments. | |||
T4035 | Khasianine | Others | |
Khasianine has strong activity against liver damage induced by CCl4. | |||
T3938 | H-HomoArg-OH.HCl | NSC 145416,L-Homoarginine hydrochloride,L(+)-Homoarginine hydrochloride | Endogenous Metabolite , Phosphorylase |
H-HomoArg-OH.HCl (L-Homoarginine hydrochloride) is a specific inhibitor of liver-type alkaline phosphatase. | |||
T24711 | Ricinine | 1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile,Ricinin,Ritsinin | Others |
Ricinine (1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile) is a major alkaloid in Ricinus communis plant with hepatoprotection in CCl4 -induced liver damage. | |||
TN1132 | Procyanidin A2 | IL Receptor , TNF , transporter , Antibacterial | |
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell... | |||
TN3548 | Bulleyanin | Others | |
Bulleyanin shows strong inhibition of mouse ehrlich ascites carcinoma (ECA), mouse sarcoma S-180, and mouse liver ascites. | |||
TWA2417 | Sodium taurocholate | Taurocholate Sodium | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and... | |||
T0361 | Isovaleramide | 3-Methylbutanamide | Dehydrogenase |
Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases. | |||
TQ0065 | Pseudobufarenogin | ψ-Bufarenogin | Others |
Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling. | |||
T8103 | H-HoArg-OH | Endogenous Metabolite , Phosphorylase | |
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human liver and bone alkaline phosphatase. | |||
T3004 | Batilol | Batilolum,Stearyl monoglyceride,Batyl alcohol,1-O-Octadecylglycerol | Others , Endogenous Metabolite |
Batilol (Stearyl monoglyceride), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent. | |||
T6S1292 | Levistolide A | Levistilide A,Diligustilide | Apoptosis , Others |
1. Levistolide A (Diligustilide) inhibits liver fibrosis and angiogenesis. | |||
T2925 | Schisandrin B | gamma-Schisandrin,Schizandrin B,Schisandrin B (Sch B),Wuweizisu-B | ATM/ATR , Reactive Oxygen Species , Autophagy |
Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart. | |||
T2S0342 | Armillarisin A | Others , Interleukin | |
Armillarisin A enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function. | |||
T5873 | 2,6-Dihydroxybenzoic acid | Endogenous Metabolite | |
2,6-Dihydroxybenzoic acid, a secondary metabolite derived from salicylic acid, undergoes hydrolyzation by liver enzymes as part of phase I metabolism. | |||
T33817 | Orellanine | 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one | Others |
Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat l... | |||
T7912 | (−)-Myrtenal | (1R)-(−)-Myrtenal | Others |
(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. | |||
TN4661 | Nodosin | IL Receptor , Autophagy | |
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp... | |||
T4586 | (Rac)-Arnebin 1 | beta, beta-dimethylacrylshikonin | Others |
(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver. | |||
TN1274 | 4-Allylcatechol | 4-Allylpyrocatechol,Hydroxychavicol | Others |
4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical ... | |||
T0281 | Meclocycline sulfosalicylate salt | Meclutin,Mecloderm,Meclan Cream | Antibacterial , Antibiotic |
Meclocycline sulfosalicylate salt (Mecloderm), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically. | |||
T0743 | DL-Carnitine | Carnitina,Carnitine | Others |
DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias. | |||
TN1650 | Friedelin | P450 , NOS , Caspase , Prostaglandin Receptor | |
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. | |||
T5S0018 | Betulonic acid | (+)-Betulonic acid,Betunolic acid,Liquidambaric acid | Parasite , HSV |
1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, wh... | |||
T2744 | Methyl Cholate | Cholic acid methyl ester | Others |
Methyl Cholate (Cholic acid methyl ester) is the methyl form of cholic acid. Cholic acid is a major bile acid produced by the liver and synthesized from cholesterol. | |||
T2731 | Usnic Acid | Usniacin | Antibacterial , Autophagy |
Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells. | |||
T3273 | Bifendate | Bifendatatum | HBV , Reverse Transcriptase |
Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury. | |||
T4854 | Acetoacetic acid lithium salt | LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate | Others , Endogenous Metabolite |
Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) is a weak organic acid that can be produced in the human liver under certain conditions of poor Metabolism leading to excessive fatty acid breakdown (diabetes mellitu... | |||
TN2179 | Saponarin | Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside | ERK , P450 , NF-κB , AMPK |
Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. | |||
T2963 | Cholic Acid | Cholanic acid,Cholate,Colalin | Endogenous Metabolite |
Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion. | |||
TN6925 | Pristane | 2,6,10,14-tetramethylpentadecane | Others |
Pristane (2,6,10,14-tetramethylpentadecane) is a natural product from shark liver oil and a non-antigenic adjuvant. | |||
------------------------ More ------------------------ |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-05352 | Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-02919 | Cadherin 17/CDH17 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-00663 | Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His) | Human | HEK293 |
Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is cal... | |||
TMPY-01912 | Cadherin 17/CDH17 Protein, Human, Recombinant (His) | Human | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPJ-01062 | HAMP Protein, Human, Recombinant (GST) | Human | E. coli |
Hepcidin(HAMP)is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron sto... | |||
TMPY-06645 | Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-01878 | L-FABP Protein, Human, Recombinant (His) | Human | E. coli |
Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid bindi... | |||
TMPH-02524 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ... | |||
TMPH-02525 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ... | |||
TMPY-04765 | PKLR Protein, Human, Recombinant (His) | Human | E. coli |
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat... | |||
TMPY-06324 | Cadherin 17/CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-00594 | Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is cal... | |||
TMPY-00446 | Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is cal... | |||
TMPJ-01174 | Cystatin B Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Cystatin B, also called stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily. Like Cystatin A, it is an intracellular inhibitor regulating the activities of cysteine proteases... | |||
TMPH-02561 | CES1C Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. | |||
TMPH-02562 | CES1C Protein, Mouse, Recombinant (His & Myc) | Mouse | HEK293 |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. | |||
TMPH-02563 | CES1C Protein, Mouse, Recombinant | Mouse | E. coli |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. | |||
TMPJ-01020 | GFER Protein, Human, Recombinant (His) | Human | E. coli |
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isofo... | |||
TMPJ-00583 | CDH17 Protein, Human, Recombinant (His) | Human | Human Cells |
Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks ... | |||
TMPY-00368 | ALR Protein, Human, Recombinant (His) | Human | HEK293 |
Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consa... | |||
TMPH-02509 | ANGPTL8 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storag... | |||
TMPH-02510 | ANGPTL8 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storag... | |||
TMPH-01091 | CHD1L Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal... | |||
TMPJ-00932 | PBLD Protein, Human, Recombinant (His) | Human | E. coli |
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is inv... | |||
TMPJ-00868 | PFKFB1 Protein, Human, Recombinant (His) | Human | Human Cells |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate... | |||
TMPJ-00593 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) | Human | Human Cells |
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the re... | |||
TMPJ-00414 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated | Human | Human Cells |
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the re... | |||
TMPH-01214 | DNASE1L3 Protein, Human, Recombinant | Human | E. coli |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... | |||
TMPH-01212 | DNASE1L3 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... | |||
TMPH-01213 | DNASE1L3 Protein, Human, Recombinant (His) | Human | Baculovirus |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... | |||
TMPJ-01156 | PHLDA2 Protein, Human, Recombinant (His) | Human | E. coli |
Pleckstrin Homology-Like Domain Family A Member 2 (PHLDA2) is a peripheral membrane protein that belongs to the PHLDA2 family. PHLDA2 is expressed in the placenta and adult prostate gland. In the placenta, it is present ... | |||
TMPJ-00053 | PRL-2 Protein, Human, Recombinant (His) | Human | E. coli |
PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational ... | |||
TMPJ-00933 | PRDX5 Protein, Human, Recombinant (His) | Human | Human Cells |
Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox... | |||
TMPJ-00506 | PSG5 Protein, Human, Recombinant (His) | Human | Human Cells |
Pregnancy-specific beta-1-glycoprotein 5, is a secreted protein which belongs to the immunoglobulin superfamily, CEA family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobuli... | |||
TMPJ-00018 | CCL16 Protein, Human, Recombinant | Human | E. coli |
CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC c... | |||
TMPY-00915 | Serpin A1 Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit... | |||
TMPY-02956 | Apolipoprotein L/APOL1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney... | |||
TMPH-01301 | Erythroferrone Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increase... | |||
TMPY-00907 | RBP4 Protein, Human, Recombinant (His) | Human | HEK293 |
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex ... | |||
TMPY-01567 | RBP4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex ... | |||
TMPY-02509 | Alpha-fetoprotein Protein, Human, Recombinant (His) | Human | HEK293 |
Alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin. AFP is a glycoprotein of 591 amino acids and a carbohydrate moie... | |||
TMPY-03014 | Osteoactivin/GPNMB Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteocla... | |||
TMPK-00114 | C-Reactive Protein /CRP Protein, Human, Recombinant (His) | Human | HEK293 |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ... | |||
TMPJ-00235 | TPO Protein, Human, Recombinant (His) | Human | Human Cells |
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of me... | |||
TMPY-00639 | EPO/Erythropoietin Protein, Human, Recombinant (hFc) | Human | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-00443 | EPO/Erythropoietin Protein, Mouse, Recombinant | Mouse | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-00925 | SOST Protein, Human, Recombinant (His) | Human | HEK293 |
Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and prima... | |||
TMPY-01633 | SOST Protein, Rat, Recombinant (His) | Rat | HEK293 |
Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and prima... | |||
TMPY-04645 | TL1A Protein, Human, Recombinant (hFc) | Human | HEK293 |
TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ... | |||
TMPJ-00842 | FGF-2 Protein, Rat, Recombinant | Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. ... | |||
------------------------ More ------------------------ |
カタログ番号 | 製品名 | ||
---|---|---|---|
L5510 | Drug-induced Liver Injury (DILI) Compound Library | 1040 compounds | |
A unique collection of 1040 hepatotoxicity causing compounds, a powerful tool for drug toxicity study, can be used for HTS and HCS screening; | |||
L2193 | Anti-Liver Cancer Compound Library | 1816 compounds | |
1816 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies. | |||
L9810 | Anti-Fibrosis Compound Library | 1180 compounds | |
A unique collection of 1180 potential anti-fibrosis compounds, can be used in HTS and HCS; | |||
L9850 | Orally Active Compound Library | 2484 compounds | |
A unique collection of 2484 of orally active compounds for high-throughput screening and high-content screening. | |||
L1120 | AMPK-Targeted Compound Library | 80 compounds | |
80 well-chosen unique AMPK-targeted small molecules; | |||
L4600 | Selected Plant-Sourced Compound Library | 3076 compounds | |
A unique collection of 3076 plant-sourced compounds that derived from 277 plant species for high throughput screening (HTS) and high content screening (HCS); | |||
L2540 | Gut Microbial Metabolite Library | 614 compounds | |
A unique collection of 614 gut microbial metabolites which can be used for HTS and HCS; | |||
L2550 | Glutamine Metabolism Compound Library | 580 compounds | |
A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ... |