Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 40,000 | |||
50 mg | 在庫あり | ¥ 74,000 | |||
100 mg | 在庫あり | ¥ 131,500 | |||
500 mg | 在庫あり | ¥ 273,500 |
説明 | MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively). |
In vitro | MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. MP-A08 blocks pro-proliferative signaling pathways causes mitochondrial-associated apoptosis in an SK-dependent manner. It also reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis [2] |
In vivo | MP-A08 inhibits the growth of human lung tumour xenografts in mice. |
分子量 | 519.64 |
分子式 | C27H25N3O4S2 |
CAS No. | 219832-49-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: insoluble
DMSO: 55 mg/mL (105.84 mM)
You can also refer to dose conversion for different animals. 詳細
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MP-A08 219832-49-2 GPCR/G Protein S1P Receptor MPA08 SphK Sphingosine kinase MP-A-08 inhibit Inhibitor MP A08 inhibitor