Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Aspirin also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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200 mg | 在庫あり | ¥ 7,500 | |||
500 mg | 在庫あり | ¥ 10,500 | |||
1 g | 在庫あり | ¥ 12,500 | |||
5 g | 在庫あり | ¥ 20,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Aspirin also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively. |
ターゲット&IC50 | COX-2:210 μg/mL, COX-1:5μg/mL |
細胞研究 | Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5]. |
別名 | Acetylsalicylate, Acetylsalicylic Acid, ASA |
分子量 | 180.16 |
分子式 | C9H8O4 |
CAS No. | 50-78-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (277.53 mM)
You can also refer to dose conversion for different animals. 詳細
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Aspirin 50-78-2 Autophagy Immunology/Inflammation Microbiology/Virology Neuroscience COX Mitophagy Virus Protease Nuclear factor-κB inhibit Inhibitor Cyclooxygenase Mitochondrial Autophagy NF-κB Nuclear factor-kappaB Antipyretic effect fever cerebrovascular thrombosis prostaglandin synthetase p38 MAPK inflammation coronary artery Acetylsalicylate Caspase Acetylsalicylic Acid platelet cancer ASA Apoptosis inhibitor