Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.
説明 | Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor. |
ターゲット&IC50 | α2-adrenoceptor:6.28(pKi ) |
In vitro | The inhibitory effect of midazolam (DG-5128) at a concentration of up to 10 μM in the cerebral cerebral membrane of [3H] clonidine is more effective than that of [3H] prazosin. The suppression method is uniform and conforms to the simple law of mass action. The EC50 values of midazolazole-induced insulin release in rat pancreatic islets and MIN6β cell lines were 200 nM and 24 μM, respectively. The IC50 values of midazolam for Kir6.2 and Kir6.2/SUR1 induced KATP current were 3.8 μM and 4.4 uM, respectively. |
In vivo | Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats[1]. |
別名 | (±)-DG5128, (±)-DG5128 hydrochloride, DG5128 hydrochloride, DG5128 |
分子量 | 324.25 |
分子式 | C16H19Cl2N3 |
CAS No. | 79689-25-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (138.78 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Midaglizole hydrochloride 79689-25-1 GPCR/G Protein Neuroscience Adrenergic Receptor (±)-DG5128 Midaglizole Hydrochloride (±)-DG5128 hydrochloride DG5128 hydrochloride DG5128 Hydrochloride DG-5128 Hydrochloride DG-5128 DG5128 DG 5128 Hydrochloride DG 5128 Inhibitor inhibitor inhibit