Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 95,000 | |||
10 mg | 在庫あり | ¥ 142,000 | |||
25 mg | 在庫あり | ¥ 226,000 | |||
50 mg | 在庫あり | ¥ 305,500 | |||
100 mg | 在庫あり | ¥ 411,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 109,000 |
説明 | NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively. |
ターゲット&IC50 | ALDH2 (human):20.1 μM , ALDH1A1:7 nM , ALDH1A3 (human):22.8 μM , ALDH1A2 (human):>57 μM , ALDH3A1 (human):>57 μM |
In vitro | NCT-505 (compound 86) is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor with IC50 of 7 nM, weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM ). NCT-505 has no significant inhibitory effect on 5-hydroxyprostaglandin dehydrogenase (HPGD) and type 4 hydroxysteroid dehydrogenase (HSD17β4) (IC50, >57 μM). In addition, NCT-505 showed potent cellular viability, reducing the viability of OV-90 cells with EC50 of 2.10-3.92 μM. NCT-505 is also cytotoxic to SKOV-3-TR cells with IC50 of 1, 3, 10, 20, 30 μM in titration analysis[1]. |
分子量 | 521.61 |
分子式 | C27H28FN5O3S |
CAS No. | 2231079-74-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (105.44 mM)
You can also refer to dose conversion for different animals. 詳細
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NCT-505 2231079-74-4 Metabolism Dehydrogenase inhibit NCT505 Aldehyde Dehydrogenase (ALDH) Inhibitor NCT 505 inhibitor