Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 18,500 | |||
50 mg | 在庫あり | ¥ 34,000 | |||
100 mg | 在庫あり | ¥ 50,000 | |||
200 mg | 在庫あり | ¥ 74,500 | |||
500 mg | 在庫あり | ¥ 125,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. |
ターゲット&IC50 | Cytochrome bc1 (human):460 nM (IC50), Cytochrome bc1 (P. falciparum):2.0 nM (IC50) |
In vitro | Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.[1] Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. [2] |
In vivo | Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. [3] |
別名 | Atavaquone |
分子量 | 366.84 |
分子式 | C22H19ClO3 |
CAS No. | 95233-18-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.67 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Atovaquone 95233-18-4 Metabolism Microbiology/Virology Others P450 Dehydrogenase Parasite Antibiotic CYPs Plasmodium malaria Cytochrome P450 Inhibitor Atavaquone neumocystis toxoplasmosis pneumonia inhibit babesia inhibitor