Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 35,500 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 89,500 | |||
100 mg | 在庫あり | ¥ 131,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 28,500 |
説明 | NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). |
ターゲット&IC50 | Kv4.3/KChIP2:5.3 μM |
In vitro | NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells[1][2]. |
別名 | NS-5806 |
分子量 | 574.07 |
分子式 | C16H8Br2F6N6O |
CAS No. | 426834-69-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (435.49 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NS5806 426834-69-7 Membrane transporter/Ion channel Potassium Channel KV4.3 Inhibitor KcsA dacay peak NS-5806 KChIP2 NS 5806 Ito KV4.2 current inhibit amplitudes inhibitor