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T84937 |
1,1'-Ethylidene-bis-(L-tryptophan)
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Peak 97 Contaminant |
Others
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1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human periphera... |
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T16348 |
NS5806
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NS-5806 |
Potassium Channel
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NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). |
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T9796 |
22393-62-0_peak 2
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Others
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22393-62-0_peak 2 exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogenic properties. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatol... |
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T9009 |
ICA-105574
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ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide |
HER
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ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel. |
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T8617 |
GMQ hydrochloride
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NSC 403387 hydrochloride |
Others
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GMQ hydrochloride (NSC-403387 hydrochloride) is a potent and selective acid-sensing ion channel (ASIC) modulator. It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current. |
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T3644 |
U93631
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GABA Receptor
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GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude... |
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T26862 |
BMS-902483
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Others
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BMS-902483 is a potent α7 partial agonist. BMS-902483 improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-... |
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T28491 |
R-1663
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R1663 |
Others
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R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner withou... |
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T70773 |
Noberastine citrate
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Others
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Noberastine citrate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapi... |
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T19304 |
EC-17 disodium salt
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Others
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EC-17 (disodium salt), a folate receptor alpha (FRα) targeting contrast agent, exhibits fluorescent properties within the visible light spectrum, characterized by peak excitation and emission wavelengths of 470/520 nm, r... |
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T83352 |
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin
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3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin serves as a pteridine-based fluorescent guanosine analogue and DNA uptake tracer utilized extensively for investigation into DNA binding and dynamics. It exhibits an... |
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T39254 |
ICG-carboxylic acid
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ICG-carboxylic acid is a fluorescent probe in the near-infrared (NIR) range. It is derived from indocyanine green (ICG), a commonly used fluorescent dye in medical diagnostics. ICG exhibits a peak absorption at 800 nm, a... |
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T32426 |
KT 1
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KT-1,KT1 |
Others
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KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood fl... |
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T37764 |
Cal Green™ 1 (potassium salt)
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Cal Green 1 is a cell-impermeant fluorescent calcium indicator that is characterized by high quantum yield and low phototoxicity. Its peak excitation and emission wavelengths (506 and 531 nm, respectively) are comparabl... |
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T71425 |
Noberastine maleate
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Others
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Noberastine maleate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapi... |
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T82726 |
Chromotrope 2R
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Chromotrope 2R functions as a chromogenic analytical probe for protein quantification, staining basic proteins red and exhibiting a peak wavelength shift from 501.6 nm to 567 nm [1]. |
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T82495 |
EGFP mRNA(N1-Me-Pseudo UTP)
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eGFP mRNA encodes the green fluorescent protein, originally derived from the jellyfish Aequorea victoria, and serves as a widely utilized direct detection reporter in mammalian cell culture. This protein produces a disti... |
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T62376 |
GNE-9278
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Others
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GNE-9278 is a highly selective NMDAR orthosteric modulator that acts on the GluN1 transmembrane structural domain (TMD).GNE-9278 acts on activated NMDAR and increases peak current and agonist affinity. |
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T84550 |
AMC Arachidonoyl Amide
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AMC-AA |
Others
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Arachidonoyl amide (AMC-AA) is a fatty acid amide among several that serve to quantify fatty acid amide hydrolase (FAAH) activity. FAAH, with its relative lack of selectivity, processes various amide head groups beyond e... |
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T41171 |
BODIPY FL VH032
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BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of ... |
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T36916 |
Estrone-3-Glucuronide (sodium salt hydrate)
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Others
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Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of ferti... |
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T71398 |
RO5126946
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Others
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RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay... |
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T74335 |
PSDalpha
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Others
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PSDalpha, an ERα degrader consisting of a photosensitizer (PS), triphenylamine benzothiadiazole (TB), and 17β-estradiol connected via an acetylene bond, demonstrates superior anti-proliferative effects on MCF-7 cells. It... |
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T35798 |
Massarigenin C
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Others
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Massarigenin C is a fungal metabolite that has been found inM. flavoroseaand has enzyme inhibitory activities.1,2Massarigenin C inhibits neuraminidasein vitro(IC50= 4.15 μM).2It is also an inhibitor of yeast α-glucosidas... |
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T39717 |
VGSC blocker-1
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Others
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VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, an... |
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T82497 |
EGFP circRNA
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eGFP circRNA, originally isolated from the jellyfish Aequorea victoria, is a reporter widely utilized for direct detection in mammalian cell culture due to its bright green fluorescence with an emission peak at 509 nm. I... |
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T85134 |
4-Methylumbelliferyl-α-D-Glucopyranoside
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4-Methylumbelliferyl-α-D-Glucoside,4-Methylumbelliferyl-α-D-Glucose,4-MU-α-D-Glucopyranoside |
Others
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4-Methylumbelliferyl-α-D-glucopyranoside serves as a fluorogenic substrate for α-glucosidase, used in enzymatic assays. This compound undergoes cleavage by α-glucosidase, releasing 4-methylumbelliferyl (4-MU), a compound... |
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T84577 |
11β-13,14-dihydro-15-keto Prostaglandin F2α
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11β-13,14-dihydro-15-keto PGF2α |
Others
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11β-13,14-Dihydro-15-keto PGF2α, a PGD2 metabolite in the 15-hydroxy PGDH pathway, is formed in human males upon infusion or inhalation of tritiated PGD2, with peak plasma levels of both 11β-PGF2α and 11β-13,14-dihydro-1... |
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T78385 |
BODIPY FL alkyne
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BOD FL alkyne |
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BODIPY FL alkyne (BOD FL alkyne) is a green-fluorescent dye with an excitation maximum at 503 nm and an emission peak at 512 nm, exhibiting bright and photostable fluorescence within the fluorescein (FAM) channel. This f... |
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T60463 |
Bifemelane
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Others
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Bifemelane is a nootropic compound that causes the first peak by stimulating release from intracellular Ca 2+ stores and the second by capacitive entry via store–operated Ca 2+ channels. Bifemelane will be offered as a p... |
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T84464 |
XLR11 Degradant
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5-FUR-144 Degradant |
Others
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XLR11, a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, exhibits enhanced affinity for the CB2 receptor, common among synthetic CBs for its receptor affinity. XLR11 degradant, a frequent impurity id... |
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TD0001 |
SYBR GREEN 1
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SYBR(R) GREEN I NUCLEIC ACID GEL STAIN *10,000× concentrate in DMSO |
Others
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SYBR Green I is an asymmetrical cyanine dye, which is used to detect nucleic acids. It consists of a N-alkylated benzothiazolium or benzoxazolium ring system, that is joined by a monomethine bridge to a pyridinium or qui... |
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TP1972 |
OD1
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Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inac... |
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T78454 |
Lucifer Yellow CH dipotassium salt
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Lucifer Yellow CH dipotassium, a high-intensity fluorescent probe featuring free hydrazyl groups, reacts with fatty aldehydes at room temperature and functions as a biological tracer for neuronal branching, regeneration,... |
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T83843 |
2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium
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2'(3')-ANT-GTP |
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2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate (2'-ANT-GTP) and 3'-ANT-GTP are fluorescent derivatives of GTP that exhibit spontaneous isomerization. 2'(3')-ANT-GTP features an emission peak at 428 nm when excited at 3... |
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T83941 |
Mag-Fura-2 AM
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Mag-Fura-2 AM, a cell-permeable fluorescent compound, serves as a selective indicator for magnesium ions (Mg2+), demonstrating significant preference for Mg2+ over other bivalent ions including zinc (Zn2+), copper (Cu2+)... |
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T83829 |
2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium
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ε-dATP |
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2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate (ε-dATP), a fluorescent derivative of 2’-deoxyadenosine-5’-O-triphosphate (dATP), promotes sister chromatid exchange in stimulated primary mouse spleen T- and B lymphocytes... |
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T13460 |
(+)-Cevimeline hydrochloride hemihydrate
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(+)-AF102B hydrochloride hemihydrate,(+)-SNI-2011 |
Others
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(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, stands as a promising therapeutic candidate for treating xerostomia in Sjogren's syndrome. This compound has demonstrated a b... |
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T13421 |
(-)-Cevimeline hydrochloride hemihydrate
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(-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate |
ALK
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Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's syndrome, exhibiting an IC50 value indicative of its affini... |
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T83802 |
TNP-ATP sodium
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TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to... |
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T83820 |
TNP-GTP sodium
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TNP-Guanosine 5'-triphosphate |
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TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity i... |
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T37880 |
OPC-167832
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Others
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OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1].
OPC-16... |
