|
T23101 |
O-3M3FBS
|
|
Others
|
|
Inactive analog of m-3M3FBS (PLC activator) |
|
T8581 |
Flecainide hydrochloride
|
|
Others
|
|
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. |
|
T4573 |
Cyclothiazide
|
|
GluR
|
|
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). |
|
T16348 |
NS5806
|
NS-5806 |
Potassium Channel
|
|
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). |
|
T23280 |
Ruthenium Red
|
Ammoniated ruthenium oxychloride |
Calcium Channel
|
|
Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ... |
|
T15286 |
Flindokalner
|
BMS-204352 |
Potassium Channel
|
|
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p... |
|
T16347 |
NS3623
|
|
Potassium Channel
|
|
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e... |
|
T1434 |
Clarithromycin
|
A-56268 |
P450
,
ribosome
,
MRP
,
Antibacterial
,
Antibiotic
,
Autophagy
|
|
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif... |
|
T2451 |
GlyH-101
|
GlyH 101 |
CFTR
,
Autophagy
|
|
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. |
|
T7775 |
A2764 dihydrochloride
|
|
Potassium Channel
|
|
A2764 dihydrochloride is a highly selective inhibitor of TRESK. |
|
T6541 |
Ibutilide Fumarate
|
Corvert Fumarate,U70226E |
Calcium Channel
,
Sodium Channel
|
|
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar... |
|
T3574 |
Sematilide hydrochloride
|
CK-1752A,CK-1752,Sematilide HCl |
Potassium Channel
|
|
Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the ... |
|
T15758 |
Linopirdine
|
DuP 996 |
Potassium Channel
,
TRP/TRPV Channel
|
|
Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhancer. It acts by stimulating rel... |
|
T9009 |
ICA-105574
|
ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide |
HER
|
|
ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel. |
|
T15207 |
Eleclazine hydrochloride
|
GS 6615 hydrochloride |
Sodium Channel
|
|
Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM). |
|
T17262 |
XE 991 dihydrochloride
|
|
Others
,
Potassium Channel
|
|
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, r... |
|
TP1858L |
Phe-Met-Arg-Phe, amide acetate
|
Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase) |
Potassium Channel
|
|
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain. |
|
T10893 |
CS-722 Free base
|
|
Others
|
|
CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-... |
|
T13374 |
YM758
|
|
Others
|
|
YM758 is an inhibitor of If current channel. |
|
T22745 |
DPO-1
|
|
Potassium Channel
|
|
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels |
|
T26016 |
R 56865
|
R-56865,R56865 |
Sodium Channel
|
|
R 56865 is a weak potential-operated channel inhibitor that inhibits the late sodium current in human isolated cardiomyocytes. |
|
T0193 |
Manidipine dihydrochloride
|
Manidipine 2HCl,CV-4093 |
Calcium Channel
|
|
Manidipine dihydrochloride (Manidipine 2HCl) is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM). |
|
T19765 |
MDK-4025
|
|
Calcium Channel
|
|
MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons. |
|
T30249 |
AZD 7009
|
AZD-7009,AZD7009 |
Sodium Channel
|
|
AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, an... |
|
T78570 |
XE991
|
|
Potassium Channel
|
|
XE991 is a novel and selective Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current, and can be used for the study of neurological disease... |
|
T1874 |
PPQ-102
|
PPQ102,CFTR Inhibitor,PPQ 102 |
CFTR
,
Autophagy
|
|
PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM). |
|
T2049 |
GS967
|
GS458967 |
Sodium Channel
|
|
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ). |
|
T31488 |
Dimethindene
|
Dimetindeno,Z 2001,Dimetindene,Z-2001,Z2001 |
Potassium Channel
,
Endogenous Metabolite
,
AChR
,
Histamine Receptor
|
|
Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects. |
|
T7505 |
Azimilide Dihydrochloride
|
NE-10064 Dihydrochloride |
Potassium Channel
|
|
Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current |
|
T21769L |
β-Pompilidotoxin Acetate
|
β-Pompilidotoxin Acetate(216064-36-7 Free base) |
Sodium Channel
|
|
β-Pompilidotoxin Acetate is a wasp venom peptide. β-Pompilidotoxin Acetate can slow sodium channel inactivation and increase steady-state sodium current in cells. |
|
T27205 |
DPI 201-106
|
DPI-201-106 |
Sodium Channel
|
|
DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents. |
|
T5585 |
AM-92016 hydrochloride
|
|
Potassium Channel
|
|
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the duration of the nerve impulse. |
|
T7578 |
REVERSE T3
|
3,3',5'-triiodo-L-thyronine |
Thyroid hormone receptor(THR)
|
|
Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes. |
|
T73267 |
VU6036720
|
|
Potassium Channel
|
|
VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit probability and single-channel current amplitude. |
|
T8839 |
ICCB280
|
|
Apoptosis
,
Others
|
|
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo... |
|
T8617 |
GMQ hydrochloride
|
NSC 403387 hydrochloride |
Others
|
|
GMQ hydrochloride (NSC-403387 hydrochloride) is a potent and selective acid-sensing ion channel (ASIC) modulator. It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current. |
|
TP1813L |
Dynorphin A 1-10 acetate(79994-24-4 free base)
|
|
Opioid Receptor
|
|
Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM. |
|
T60224 |
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
|
|
GluR
|
|
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986. S 18986 is a AMPA receptor positive modulator with EC2 (Concentration that doubles the intensity of... |
|
T0207 |
Ranolazine dihydrochloride
|
RS 43285,Ranolazine 2HCl |
Calcium Channel
,
Sodium Channel
,
Autophagy
|
|
Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or h... |
|
T0866 |
Propafenone
|
Rythmol,Propafenonum |
Potassium Channel
,
MRP
,
Sodium Channel
|
|
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.... |
|
T15555 |
IK1 inhibitor PA-6
|
|
Potassium Channel
|
|
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse KIR2.x currents). |
|
T6476 |
Dofetilide
|
UK 68789,UK-68798,Tikosyn |
Potassium Channel
|
|
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik... |
|
T1046 |
Mexiletine hydrochloride
|
KOE-1173 (hydrochloride),Mexiletine HCl,KO1173 |
AhR
,
Sodium Channel
|
|
Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myoca... |
|
T16516 |
PG01
|
Phenylglycine-01 |
CFTR
|
|
|
|
TP1942L1 |
Pep2-AVKI acetate(1315378-69-8 free base)
|
|
Others
|
|
pep2-AVKI acetate(1315378-69-8 free base) An inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to proteins that interact with C-kinase (PICK1). Does not a... |
|
TP1884L1 |
Neuropeptide SF(mouse,rat) acetate
|
Neuropeptide SF(mouse,rat) acetate(230960-31-3 free base) |
Neuropeptide Y Receptor
|
|
Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) is a potent neuropeptide FF receptor agonist, Ki for NPFF1 and NPFF2 are 48.4 nM and 12.1 nM, respectively. Neuropeptide SF(... |
|
T2535 |
Ivabradine hydrochloride
|
S 16257-2,Ivabradine HCl |
Adrenergic Receptor
|
|
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat... |
|
T27117 |
DA-6886
|
DA6886,DA 6886 |
5-HT Receptor
|
|
DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressin... |
|
T32191 |
Irdabisant
|
CEP-26401,CEP 26401,CEP26401 |
Histamine Receptor
|
|
Irdabisant (CEP-26401) (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant antagonist/inverse agonist of histamine H3 receptor (H3R) (rat H3R Ki= 7.2 nM, human H3R Ki= 2.0 nM). Irdabisant ex... |
|
T2170 |
SKF-96365 hydrochloride
|
SKF96365 |
Apoptosis
,
Potassium Channel
,
Calcium Channel
,
TRP/TRPV Channel
,
Autophagy
|
|
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha... |
