Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nemiralisib(GSK-2269557 free base) is an orally available, potent and specific PI3Kδ inhibitor with a pKi of 9.9.Nemiralisib is used for the treatment of respiratory diseases including chronic obstructive pulmonary disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
2 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 21,000 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 68,500 | |||
50 mg | 在庫あり | ¥ 109,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 23,000 |
説明 | Nemiralisib(GSK-2269557 free base) is an orally available, potent and specific PI3Kδ inhibitor with a pKi of 9.9.Nemiralisib is used for the treatment of respiratory diseases including chronic obstructive pulmonary disease. |
ターゲット&IC50 | PI3Kδ:9.9 (pki), PI3Kβ:5.8 (pic50), PI3Kα:5.3 (pic50), PI3Kγ:5.2 (pic50) |
In vitro | Nemiralisib inhibits IFNγ in the peripheral blood mononuclear (PBMC) (pIC50: 9.7). Nemiralisib is highly selective for PI3Kδ. It has >1000-fold selectivity over the closely related isoforms PI3Kα (pIC50: 5.3), PI3Kβ (pIC50: 5.8), and PI3Kγ (pIC50: 5.2).[1] |
In vivo | Nemiralisib is active in a disease-relevant brown Norway rat acute OVA model of Type 2 helper T-cells (Th2)-driven lung inflammation. Pharmacokinetic data from Sprague Dawley male rats are obtained to assess the suitability of the series for inhaled delivery clearance data in rat microsomes and subsequently in vivo. Compounds (e.g., Nemiralisib) are administered by the oral or intravenous routes, at a dose level of 3 and 1mg/kg respectively (n=2 rats/route).[1] |
別名 | GSK2269557 (free base), GSK2269557 |
分子量 | 440.54 |
分子式 | C26H28N6O |
CAS No. | 1254036-71-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 29 mg/mL (65.83 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Nemiralisib 1254036-71-9 PI3K/Akt/mTOR signaling PI3K GSK 2269557 GSK2269557 (free base) GSK2269557 GSK-2269557 Inhibitor inhibitor inhibit