Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-8130 is an orally available antagonist of EP1 receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 37,500 | |||
5 mg | 在庫あり | ¥ 83,000 | |||
10 mg | 在庫あり | ¥ 136,000 | |||
25 mg | 在庫あり | ¥ 217,500 | |||
50 mg | 在庫あり | ¥ 296,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 110,500 |
説明 | ONO-8130 is an orally available antagonist of EP1 receptor. |
In vivo | Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.?Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.?Intravesical administration of prostaglandin E2 caused prompt phosphorylation of ERK in the L6 spinal cord, an effect blocked by ONO-8130.?The prostaglandin E2/EP1 system participates in processing of cystitis-related bladder pain, and that EP1 antagonists including ONO-8130 are useful for treatment of bladder pain, particularly in interstitial cystitis.?Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists[1]. |
分子量 | 500.63 |
分子式 | C25H28N2O5S2 |
CAS No. | 459841-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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ONO-8130 459841-96-4 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor Orally active Inhibitor inhibit Bladder pain Interstitial cystitis PKR-like endoplasmic reticulum kinase PERK Hyperalgesia Protein kinase R-like endoplasmic reticulum kinase ONO8130 ONO 8130 inhibitor