store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 7,500 | |||
50 mg | 在庫あり | ¥ 10,500 | |||
100 mg | 在庫あり | ¥ 14,500 | |||
200 mg | 在庫あり | ¥ 20,500 | |||
500 mg | 在庫あり | ¥ 33,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
ターゲット&IC50 | PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50) |
In vitro | Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2] |
別名 | BRL-49653 HCl, Rosiglitazone HCl |
分子量 | 393.89 |
分子式 | C18H19N3O3S·HCl |
CAS No. | 302543-62-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 73 mg/mL (185.3 mM)
DMSO: 73 mg/mL (185.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rosiglitazone hydrochloride 302543-62-0 Apoptosis Autophagy DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism TRP/TRPV Channel Ferroptosis PPAR mellitus hepatocellular antihyperglycemic Inhibitor cancer senescence Rosiglitazone PPARγ BRL-49653 HCC diabetic carcinoma BRL49653 bladder BRL-49653 HCl neuroprotection BRL 49653 Rosiglitazone Hydrochloride diabetes TRP Channel ovarian cancer smoke Rosiglitazone HCl inhibit Transient receptor potential channels Peroxisome proliferator-activated receptors inhibitor