store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits breast cancer cell growth in vitro and selectively induces apoptosis in leukemia cells via c-Jun NH2 terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 12,500 |
2 mg | 在庫あり | ¥ 17,500 |
5 mg | 在庫あり | ¥ 31,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 33,000 |
説明 | PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits breast cancer cell growth in vitro and selectively induces apoptosis in leukemia cells via c-Jun NH2 terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL. |
In vitro | PBOX 6, a potent apoptotic PBOX, does not elicit a general toxic effect in a rat R2C Leydig cell line. Treatment with PBOX 6 (0-25 μM, 16 h) induces dose- and time-dependent apoptosis and causes DNA fragmentation at 10 μM in HL-60 cells. Additionally, PBOX 6 (10 μM) induces apoptosis through the activation of caspase 3-like proteases in HL-60 cells. The apoptotic induction by PBOX 6 (10 μM) also leads to the accumulation of cytochrome c in the cytosol, independent of oxidative stress, peripheral-type benzodiazepine receptor (PBR), and NF-κB[1]. In MCF-7 cells, PBOX 6 (25 μM) induces apoptosis through the activation of caspase-7[3]. Furthermore, in K562 cells, PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol and nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner. This effect is also dependent on upstream activation of a trypsin-like serine protease, correlating with G2/M arrest[2]. |
別名 | PBOX-6 |
分子量 | 396.44 |
分子式 | C25H20N2O3 |
CAS No. | 290814-68-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (75.67 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PBOX 6 290814-68-5 Apoptosis PBOX-6 PBOX6 Inhibitor inhibitor inhibit