Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
500 mg | 在庫あり | ¥ 10,500 | |||
1 g | お問い合わせ | ¥ 13,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation. |
In vitro | In murine and rat brain allografts, the combination of Azathioprine with Cyclosporin A or Prednisolone significantly enhances survival rates. |
In vivo | Azathioprine inhibits Rac1 target genes in primary human CD4+ T lymphocytes, leading to apoptosis via the mitochondrial pathway. In isolated rat hepatocytes, Azathioprine depletes reduced glutathione (GSH), releases lactate dehydrogenase, and decreases cellular viability. |
別名 | BW 57-322 |
分子量 | 277.26 |
分子式 | C9H7N7O2S |
CAS No. | 446-86-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.7 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Azathioprine 446-86-6 Apoptosis Cell Cycle/Checkpoint Endocrinology/Hormones GPCR/G Protein GPR Rho Rheumatic diseases Infectious skin diseases BW 57-322 inhibit Autoimmunity inhibitor Inhibitor 6-Mercaptopurine inhibitor