Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF 06446846 is a potent and selective PCSK9 inhibitor
説明 | PF 06446846 is a potent and selective PCSK9 inhibitor |
In vivo | PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts. |
分子量 | 433.89 |
分子式 | C22H20ClN7O |
CAS No. | 1632250-49-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.34 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PF-06446846 1632250-49-7 Others Threonine proteases PF 06446846 Inhibitor 80S ribosome Selective Ser/Thr Protease Serine proteases Rat bone marrow Huh7 inhibit PF06446846 Serine endopeptidases inhibitor