|
T6759 |
AP-III-a4
|
ENOblock |
Glucokinase
|
|
AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM. |
|
T4235 |
Roblitinib
|
FGF-401 |
FGFR
|
|
Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads ... |
|
T8645 |
PF-06446846
|
|
Others
|
|
PF 06446846 is a potent and selective PCSK9 inhibitor |
|
T4264 |
Takinib
|
EDHS-206 |
Apoptosis
,
MAPK
|
|
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM). |
|
T9518 |
Inarigivir ammonium
|
ORI-9020 ammonium,SB-9200 ammonium |
HBV
|
|
Inarigivir ammonium (SB-9200 ammonium) is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (... |
|
T1900 |
LDN-212854
|
LDN212854,BMP Inhibitor III |
ALK
,
TGF-beta/Smad
|
|
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors. |
|
T27835 |
Lin281632
|
Lin-28 1632,Lin-281632,Lin 281632,Lin28 1632,Lin 28 163 |
|
|
Lin28 1632 is an inhibitor of RNA binding protein Lin28. It promotes mESC differentiation. Lin281632 is also bromodomain inhibitor. |
|
T4686 |
Simeprevir
|
TMC435,TMC-435350,Olysio |
HCV Protease
,
SARS-CoV
|
|
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM. |
|
T5863 |
Indinavir sulfate
|
L735524 sulfate,MK-639 sulfate |
SARS-CoV
,
HIV Protease
|
|
Indinavir sulfate (L735524 sulfate) is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. |
|
T83658 |
SQLE-IN-1
|
|
Antifungal
|
|
SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the... |
|
T9249 |
ITMN4077
|
|
Antiviral
|
|
ITMN4077 has antiviral activity against Hepatitis C virus infected in human HuH7 cells assessed as inhibition of HCV subgenomic replicon replication with an EC50 of 2.131μM. |
|
T38238 |
2'-Deoxy-2'-fluorocytidine
|
|
Nucleoside Antimetabolite/Analog
,
Influenza Virus
|
|
2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency o... |
|
T27733 |
KKJ00626
|
KKJ-00626,KKJ 00626 |
|
|
KKJ00626, an inhibitor of HBV virus, inhibits HBV replication in transfected Huh7 cells. |
|
T79271 |
FGFR4-IN-14
|
|
FGFR
|
|
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutant strains. Specifically, it registers IC50 values of 21 nM aga... |
|
T27750 |
KSJ0001
|
KSJ-0001,KSJ 0001 |
|
|
KSJ0001, a HBV virus inhibitor, inhibits HBV replication in transfected Huh7 cells. |
|
T61946 |
IMP2-IN-1
|
|
|
|
IMP2-IN-1 (compound 4) is an effective IMP2 inhibitor with an IC50 of 81.3-127.5 μM for IMP2 RNA . IMP2-IN-1 decreased the level of IMP2 in SW480 cells. IMP2-IN-1 significantly inhibited the activity of differentiated an... |
|
T79332 |
Antiproliferative agent-32
|
|
Apoptosis
|
|
Antiproliferative agent-32 (Compound 1c) impedes phosphorylation within the PI3K/Akt/mTOR signaling pathway, restrains proliferation of Huh7 and SK-Hep-1 cells, induces apoptosis, and inflicts mitochondrial damage, rende... |
|
T36668 |
Geranylgeranoic Acid
|
|
|
|
Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not... |
|
T37039 |
Betulinic Aldehyde oxime
|
|
|
|
Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as w... |
|
T61045 |
Topoisomerase I/II inhibitor 2
|
|
|
|
Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i... |
|
T35547 |
YW1128
|
|
|
|
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein ... |
|
T83714 |
LAP TFA
|
Lupus Autoantigen Peptide,La Peptide |
|
|
Lupus autoantigen peptide (LAP), a derivative of the autoantigen La found in systemic lupus erythematosus (SLE) patients, spans amino acids 11-28 of La and functions as an antiviral peptide. It primarily blocks the hepat... |
|
T82189 |
HMGB1-IN-2
|
|
|
|
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces... |
|
T15675 |
Tirbanibulin Mesylate
|
KX2-391 Mesylate,KX01 Mesylate |
Microtubule Associated
,
Src
|
|
Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines). |
|
T36848 |
Combretastatin A-1
|
Combretastatin A1 |
Akt
,
Microtubule Associated
|
|
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and... |
|
T38269 |
Purfalcamine
|
|
|
|
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes mala... |
