Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
説明 | PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia. |
ターゲット&IC50 | α7 nAChR:8.8 nM (Ki) |
In vivo | In rats, PHA-543613 (0.3 mg/kg) reverses Scopolamine-induced short-term memory deficits[2]. Intraperitoneal injection of PHA-543613 (4 and 12 mg/kg) increases p-Akt and decreases p-GSK-3 and CC3 expressions in the ipsilateral hemisphere. PHA-543613 reduces neuronal cell death in the perihematomal area[3]. |
分子量 | 271.31 |
分子式 | C15H17N3O2 |
CAS No. | 478149-53-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (829.3 mM), Sonication is recommended.
H2O: < 30.78 mg/mL
You can also refer to dose conversion for different animals. 詳細
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PHA 543613 478149-53-0 Neuroscience Others AChR PHA543613 PHA-543613 PHA 543613 hydrochloride Inhibitor inhibitor inhibit