Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.
説明 | TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders. |
In vitro | TMPH (100 nM) inhibits nAChR with an inhibition rate of 90% in Xenopus oocytes and suppresses AChR subtypes with IC50s of 1.0-390 nM[1]. |
In vivo | In the nicotine-induced mice model, nAChR-IN-1 (20 mg/kg; s.c.) increases locomotor activity without effects on body temperature. In the tail-flick and hot-plate mice model, nAChR-IN-1(0, 0.1, 1, 5 mg/kg; s.c.) blocks the antinociceptive effect of nicotine in the hot-plate and blocks antinociception in a time-dependent manner[1]. |
別名 | 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate |
分子量 | 269.42 |
分子式 | C16H31NO2 |
CAS No. | 849461-90-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (185.58 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TMPH 849461-90-1 Neuroscience AChR neurol disorder nAChR Nicotinic acetylcholine receptors neuronal nicotinic receptors selective inhibition Inhibitor inhibit nicotinic receptor brain function tetramethylpiperidinyl heptanoate 2,2,6,6-Tetramethylpiperidin-4-yl Heptanoate dysfunction 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate inhibitor