Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 150,500 |
5 mg | 在庫あり | ¥ 296,000 |
10 mg | 在庫あり | ¥ 397,000 |
25 mg | 在庫あり | ¥ 594,500 |
50 mg | 在庫あり | ¥ 799,000 |
100 mg | 在庫あり | ¥ 1,083,500 |
説明 | PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively. |
ターゲット&IC50 | mTOR:10.6 nM (ki), PI3Kα:12.5 nM (ki), PI3Kα:7 nM (Cell Assay) |
In vitro | PI3Kα/mTOR-IN-1 exhibited excellent kinase selectivity from Pfizer’s in-house kinase selectivity panel of 43 kinases[1]. |
In vivo | PI3Kα/mTOR-IN-1 exhibited exhibited moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1]. |
分子量 | 310.35 |
分子式 | C16H18N6O |
CAS No. | 1013098-90-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (35.44 mM)
You can also refer to dose conversion for different animals. 詳細
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PI3Kα/mTOR-IN-1 1013098-90-2 PI3K/Akt/mTOR signaling PI3K mTOR PI3Kα/mTORIN1 PI3Kalpha/mTOR-IN-1 PI3Kα/mTOR IN 1 PI3Ka/mTOR-IN-1 PI-3Kα/mTOR-IN-1 Inhibitor inhibitor inhibit